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PubMed:23530032 JSONTXT 23 Projects

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Id Subject Object Predicate Lexical cue
T1 0-150 Sentence denotes The central nervous system (CNS)-independent anti-bone-resorptive activity of muscle contraction and the underlying molecular and cellular signatures.
T2 151-162 Sentence denotes BACKGROUND:
T3 163-227 Sentence denotes Mechanisms by which muscle regulates bone are poorly understood.
T4 228-236 Sentence denotes RESULTS:
T5 237-399 Sentence denotes Electrically stimulated muscle contraction reversed elevations in bone resorption and increased Wnt signaling in bone-derived cells after spinal cord transection.
T6 400-411 Sentence denotes CONCLUSION:
T7 412-576 Sentence denotes Muscle contraction reduced resorption of unloaded bone independently of the CNS, through mechanical effects and, potentially, nonmechanical signals (e.g. myokines).
T8 577-590 Sentence denotes SIGNIFICANCE:
T9 591-658 Sentence denotes The study provides new insights regarding muscle-bone interactions.
T10 659-701 Sentence denotes Muscle and bone work as a functional unit.
T11 702-807 Sentence denotes Cellular and molecular mechanisms underlying effects of muscle activity on bone mass are largely unknown.
T12 808-975 Sentence denotes Spinal cord injury (SCI) causes muscle paralysis and extensive sublesional bone loss and disrupts neural connections between the central nervous system (CNS) and bone.
T13 976-1094 Sentence denotes Muscle contraction elicited by electrical stimulation (ES) of nerves partially protects against SCI-related bone loss.
T14 1095-1280 Sentence denotes Thus, application of ES after SCI provides an opportunity to study the effects of muscle activity on bone and roles of the CNS in this interaction, as well as the underlying mechanisms.
T15 1281-1379 Sentence denotes Using a rat model of SCI, the effects on bone of ES-induced muscle contraction were characterized.
T16 1380-1493 Sentence denotes The SCI-mediated increase in serum C-terminal telopeptide of type I collagen (CTX) was completely reversed by ES.
T17 1494-1904 Sentence denotes In ex vivo bone marrow cell cultures, SCI increased the number of osteoclasts and their expression of mRNA for several osteoclast differentiation markers, whereas ES significantly reduced these changes; SCI decreased osteoblast numbers, but increased expression in these cells of receptor activator of NF-κB ligand (RANKL) mRNA, whereas ES increased expression of osteoprotegerin (OPG) and the OPG/RANKL ratio.
T18 1905-2155 Sentence denotes A microarray analysis revealed that ES partially reversed SCI-induced alterations in expression of genes involved in signaling through Wnt, FSH, parathyroid hormone (PTH), oxytocin, and calcineurin/nuclear factor of activated T-cells (NFAT) pathways.
T19 2156-2290 Sentence denotes ES mitigated SCI-mediated increases in mRNA levels for the Wnt inhibitors DKK1, sFRP2, and sclerostin in ex vivo cultured osteoblasts.
T20 2291-2428 Sentence denotes Our results demonstrate an anti-bone-resorptive activity of muscle contraction by ES that develops rapidly and is independent of the CNS.
T21 2429-2549 Sentence denotes The pathways involved, particularly Wnt signaling, suggest future strategies to minimize bone loss after immobilization.