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Id Subject Object Predicate Lexical cue
T1 0-118 Sentence denotes Vitellogenin receptor mutation leads to the oogenesis mutant phenotype "scanty vitellin" of the silkworm, Bombyx mori.
T2 119-130 Sentence denotes BACKGROUND:
T3 131-245 Sentence denotes The vitellogenin receptor (VgR) mediates the uptake of vitellogenin (Vg) from the hemolymph by developing oocytes.
T4 246-254 Sentence denotes RESULTS:
T5 255-366 Sentence denotes VgR with the mutational EGF1 domain can bind ligand proteins but cannot be dissociated under acidic conditions.
T6 367-399 Sentence denotes The mutant is lethal in embryos.
T7 400-411 Sentence denotes CONCLUSION:
T8 412-501 Sentence denotes Bombyx mori VgR (BmVgR) has an important role in egg formation and embryonic development.
T9 502-515 Sentence denotes SIGNIFICANCE:
T10 516-561 Sentence denotes BmVgR is a potential target for pest control.
T11 562-688 Sentence denotes In insects, the vitellogenin receptor (VgR) mediates the uptake of vitellogenin (Vg) from the hemolymph by developing oocytes.
T12 689-841 Sentence denotes The oogenesis mutant scanty vitellin (vit) of Bombyx mori (Bm) lacks vitellin and 30-kDa proteins, but B. mori egg-specific protein and BmVg are normal.
T13 842-954 Sentence denotes The vit eggs are white and smaller compared with the pale yellow eggs of the wild type and are embryonic lethal.
T14 955-1057 Sentence denotes This study found that a mutation in the B. mori VgR gene (BmVgR) is responsible for the vit phenotype.
T15 1058-1113 Sentence denotes We cloned the cDNA sequences encoding WT and vit BmVgR.
T16 1114-1210 Sentence denotes The functional domains of BmVgR are similar to those of other low-density lipoprotein receptors.
T17 1211-1319 Sentence denotes When compared with the wild type, a 235-bp genomic sequence in vit BmVgR is substituted for a 7-bp sequence.
T18 1320-1454 Sentence denotes This mutation has resulted in a 50-amino acid deletion in the third Class B region of the first epidermal growth factor (EGF1) domain.
T19 1455-1632 Sentence denotes BmVgR is expressed specifically in oocytes, and the transcriptional level is changed dramatically and consistently with maturation of oocytes during the previtellogenic periods.
T20 1633-1700 Sentence denotes Linkage analysis confirmed that BmVgR is mutated in the vit mutant.
T21 1701-1843 Sentence denotes The coimmunoprecipitation assay confirmed that mutated BmVgR is able to bind BmVg but that BmVg cannot be dissociated under acidic conditions.
T22 1844-1994 Sentence denotes The WT phenotype determined by RNA interference was similar to that of the vit phenotype for nutritional deficiency, such as BmVg and 30-kDa proteins.
T23 1995-2129 Sentence denotes These results showed that BmVgR has an important role in transporting proteins for egg formation and embryonic development in B. mori.