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Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-74 Sentence denotes Glycosaminoglycans in the blood of hereditary multiple exostoses patients:
T1 0-74 Sentence denotes Glycosaminoglycans in the blood of hereditary multiple exostoses patients:
T1 0-74 Sentence denotes Glycosaminoglycans in the blood of hereditary multiple exostoses patients:
TextSentencer_T2 75-178 Sentence denotes Half reduction of heparan sulfate to chondroitin sulfate ratio and the possible diagnostic application.
T2 75-178 Sentence denotes Half reduction of heparan sulfate to chondroitin sulfate ratio and the possible diagnostic application.
T2 75-178 Sentence denotes Half reduction of heparan sulfate to chondroitin sulfate ratio and the possible diagnostic application.
TextSentencer_T3 179-511 Sentence denotes Hereditary multiple exostoses (HME) is an autosomal dominant skeletal disorder with wide variation in clinical phenotype and is caused by heterogeneous germline mutations in two of the Ext genes, EXT-1 and EXT-2, which encode ubiquitously expressed glycosyltransferases involved in the polymerization of heparan sulfate (HS) chains.
T3 179-511 Sentence denotes Hereditary multiple exostoses (HME) is an autosomal dominant skeletal disorder with wide variation in clinical phenotype and is caused by heterogeneous germline mutations in two of the Ext genes, EXT-1 and EXT-2, which encode ubiquitously expressed glycosyltransferases involved in the polymerization of heparan sulfate (HS) chains.
T3 179-511 Sentence denotes Hereditary multiple exostoses (HME) is an autosomal dominant skeletal disorder with wide variation in clinical phenotype and is caused by heterogeneous germline mutations in two of the Ext genes, EXT-1 and EXT-2, which encode ubiquitously expressed glycosyltransferases involved in the polymerization of heparan sulfate (HS) chains.
TextSentencer_T4 512-812 Sentence denotes To examine whether the Ext mutation could affect HS structures and amounts in HME patients being heterozygous for the Ext genes, we collected blood from patients and healthy individuals, separated it into plasma and cellular fractions and then isolated glycosaminoglycans (GAGs) from those fractions.
T4 512-812 Sentence denotes To examine whether the Ext mutation could affect HS structures and amounts in HME patients being heterozygous for the Ext genes, we collected blood from patients and healthy individuals, separated it into plasma and cellular fractions and then isolated glycosaminoglycans (GAGs) from those fractions.
T4 512-812 Sentence denotes To examine whether the Ext mutation could affect HS structures and amounts in HME patients being heterozygous for the Ext genes, we collected blood from patients and healthy individuals, separated it into plasma and cellular fractions and then isolated glycosaminoglycans (GAGs) from those fractions.
TextSentencer_T5 813-1186 Sentence denotes A newly established method consisting of a combination of selective ethanol precipitation of GAGs, digestion of GAGs recovered on the filter-cup by direct addition of heparitinase or chondroitinase reaction solution and subsequent high-performance liquid chromatography of the unsaturated disaccharide products enabled the analysis using the least amount of blood (200 µL).
T5 813-1186 Sentence denotes A newly established method consisting of a combination of selective ethanol precipitation of GAGs, digestion of GAGs recovered on the filter-cup by direct addition of heparitinase or chondroitinase reaction solution and subsequent high-performance liquid chromatography of the unsaturated disaccharide products enabled the analysis using the least amount of blood (200 µL).
T5 813-1186 Sentence denotes A newly established method consisting of a combination of selective ethanol precipitation of GAGs, digestion of GAGs recovered on the filter-cup by direct addition of heparitinase or chondroitinase reaction solution and subsequent high-performance liquid chromatography of the unsaturated disaccharide products enabled the analysis using the least amount of blood (200 µL).
TextSentencer_T6 1187-1310 Sentence denotes We found that HS structures of HME patients were almost similar to those of controls in both plasma and cellular fractions.
T6 1187-1310 Sentence denotes We found that HS structures of HME patients were almost similar to those of controls in both plasma and cellular fractions.
T6 1187-1310 Sentence denotes We found that HS structures of HME patients were almost similar to those of controls in both plasma and cellular fractions.
TextSentencer_T7 1311-1645 Sentence denotes However, interestingly, although both the amounts of HS and chondroitin sulfate (CS) varied depending on the different individuals, the amounts of HS in both the plasma and cellular fractions of HME patient samples were decreased and the ratios of HS to CS (HS/CS) of HME patient samples were almost half those of healthy individuals.
T7 1311-1645 Sentence denotes However, interestingly, although both the amounts of HS and chondroitin sulfate (CS) varied depending on the different individuals, the amounts of HS in both the plasma and cellular fractions of HME patient samples were decreased and the ratios of HS to CS (HS/CS) of HME patient samples were almost half those of healthy individuals.
T7 1311-1645 Sentence denotes However, interestingly, although both the amounts of HS and chondroitin sulfate (CS) varied depending on the different individuals, the amounts of HS in both the plasma and cellular fractions of HME patient samples were decreased and the ratios of HS to CS (HS/CS) of HME patient samples were almost half those of healthy individuals.
TextSentencer_T8 1646-1792 Sentence denotes The results suggest that HME patients' blood exhibited reduced HS amounts and HS/CS ratios, which could be used as a diagnostic biomarker for HME.
T8 1646-1792 Sentence denotes The results suggest that HME patients' blood exhibited reduced HS amounts and HS/CS ratios, which could be used as a diagnostic biomarker for HME.
T8 1646-1792 Sentence denotes The results suggest that HME patients' blood exhibited reduced HS amounts and HS/CS ratios, which could be used as a diagnostic biomarker for HME.