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PubMed:23508958 JSONTXT 30 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-118 Sentence denotes Excitation and modulation of TRPA1, TRPV1, and TRPM8 channel-expressing sensory neurons by the pruritogen chloroquine.
T1 0-118 Sentence denotes Excitation and modulation of TRPA1, TRPV1, and TRPM8 channel-expressing sensory neurons by the pruritogen chloroquine.
TextSentencer_T2 119-189 Sentence denotes The sensations of pain, itch, and cold often interact with each other.
T2 119-189 Sentence denotes The sensations of pain, itch, and cold often interact with each other.
TextSentencer_T3 190-251 Sentence denotes Pain inhibits itch, whereas cold inhibits both pain and itch.
T3 190-251 Sentence denotes Pain inhibits itch, whereas cold inhibits both pain and itch.
TextSentencer_T4 252-332 Sentence denotes TRPV1 and TRPA1 channels transduce pain and itch, whereas TRPM8 transduces cold.
T4 252-332 Sentence denotes TRPV1 and TRPA1 channels transduce pain and itch, whereas TRPM8 transduces cold.
TextSentencer_T5 333-428 Sentence denotes The pruritogen chloroquine (CQ) was reported to excite TRPA1, leading to the sensation of itch.
T5 333-428 Sentence denotes The pruritogen chloroquine (CQ) was reported to excite TRPA1, leading to the sensation of itch.
TextSentencer_T6 429-569 Sentence denotes It is unclear how CQ excites and modulates TRPA1(+), TRPV1(+), and TRPM8(+) neurons and thus affects the sensations of pain, itch, and cold.
T6 429-569 Sentence denotes It is unclear how CQ excites and modulates TRPA1(+), TRPV1(+), and TRPM8(+) neurons and thus affects the sensations of pain, itch, and cold.
TextSentencer_T7 570-762 Sentence denotes Here, we show that only 43% of CQ-excited dorsal root ganglion neurons expressed TRPA1; as expected, the responses of these neurons were completely prevented by the TRPA1 antagonist HC-030031.
T7 570-762 Sentence denotes Here, we show that only 43% of CQ-excited dorsal root ganglion neurons expressed TRPA1; as expected, the responses of these neurons were completely prevented by the TRPA1 antagonist HC-030031.
TextSentencer_T8 763-1036 Sentence denotes The remaining 57% of CQ-excited neurons did not express TRPA1, and excitation was not prevented by either a TRPA1 or TRPV1 antagonist but was prevented by the general transient receptor potential canonical (TRPC) channel blocker BTP2 and the selective TRPC3 inhibitor Pyr3.
T8 763-1036 Sentence denotes The remaining 57% of CQ-excited neurons did not express TRPA1, and excitation was not prevented by either a TRPA1 or TRPV1 antagonist but was prevented by the general transient receptor potential canonical (TRPC) channel blocker BTP2 and the selective TRPC3 inhibitor Pyr3.
TextSentencer_T9 1037-1205 Sentence denotes Furthermore, CQ caused potent sensitization of TRPV1 in 51.9% of TRPV1(+) neurons and concomitant inhibition of TRPM8 in 48.8% of TRPM8(+) dorsal root ganglion neurons.
T9 1037-1205 Sentence denotes Furthermore, CQ caused potent sensitization of TRPV1 in 51.9% of TRPV1(+) neurons and concomitant inhibition of TRPM8 in 48.8% of TRPM8(+) dorsal root ganglion neurons.
TextSentencer_T10 1206-1343 Sentence denotes Sensitization of TRPV1 is caused mainly by activation of the phospholipase C-PKC pathway following activation of the CQ receptor MrgprA3.
T10 1206-1343 Sentence denotes Sensitization of TRPV1 is caused mainly by activation of the phospholipase C-PKC pathway following activation of the CQ receptor MrgprA3.
TextSentencer_T11 1344-1466 Sentence denotes By contrast, inhibition of TRPM8 is caused by a direct action of activated Gαq independent of the phospholipase C pathway.
T11 1344-1466 Sentence denotes By contrast, inhibition of TRPM8 is caused by a direct action of activated Gαq independent of the phospholipase C pathway.
TextSentencer_T12 1467-1575 Sentence denotes Our data suggest the involvement of the TRPC3 channel acting together with TRPA1 to mediate CQ-induced itch.
T12 1467-1575 Sentence denotes Our data suggest the involvement of the TRPC3 channel acting together with TRPA1 to mediate CQ-induced itch.
TextSentencer_T13 1576-1781 Sentence denotes CQ not only elicits itch by directly exciting itch-encoding neurons but also exerts previously unappreciated widespread actions on pain-, itch-, and cold-sensing neurons, leading to enhanced pain and itch.
T13 1576-1781 Sentence denotes CQ not only elicits itch by directly exciting itch-encoding neurons but also exerts previously unappreciated widespread actions on pain-, itch-, and cold-sensing neurons, leading to enhanced pain and itch.