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PubMed:23461584 JSONTXT 8 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-47 Sentence denotes RET inhibition: implications in cancer therapy.
T1 0-47 Sentence denotes RET inhibition: implications in cancer therapy.
TextSentencer_T2 48-61 Sentence denotes INTRODUCTION:
T2 48-61 Sentence denotes INTRODUCTION:
TextSentencer_T3 62-177 Sentence denotes The RET gene encodes a receptor tyrosine kinase essential for ontogenesis of the enteric nervous system and kidney.
T3 62-177 Sentence denotes The RET gene encodes a receptor tyrosine kinase essential for ontogenesis of the enteric nervous system and kidney.
TextSentencer_T4 178-358 Sentence denotes Following identification of RET, it was found that somatic rearrangements of this gene, conventionally designated as RET/PTC, are frequently present in papillary thyroid carcinoma.
T4 178-358 Sentence denotes Following identification of RET, it was found that somatic rearrangements of this gene, conventionally designated as RET/PTC, are frequently present in papillary thyroid carcinoma.
TextSentencer_T5 359-533 Sentence denotes Subsequently, activating germ line point mutations of RET were identified as being responsible for the hereditary medullary thyroid carcinoma syndromes MEN2A, MEN2B and FMTC.
T5 359-533 Sentence denotes Subsequently, activating germ line point mutations of RET were identified as being responsible for the hereditary medullary thyroid carcinoma syndromes MEN2A, MEN2B and FMTC.
TextSentencer_T6 534-627 Sentence denotes RET rearrangements have recently been identified in a small fraction of lung adenocarcinomas.
T6 534-627 Sentence denotes RET rearrangements have recently been identified in a small fraction of lung adenocarcinomas.
TextSentencer_T7 628-641 Sentence denotes AREA COVERED:
T7 628-641 Sentence denotes AREA COVERED:
TextSentencer_T8 642-874 Sentence denotes The authors review the current field concerning the RET gene and protein, its involvement in cancer and the preclinical and clinical studies which highlight its role as a potentially important therapeutic target for several cancers.
T8 642-874 Sentence denotes The authors review the current field concerning the RET gene and protein, its involvement in cancer and the preclinical and clinical studies which highlight its role as a potentially important therapeutic target for several cancers.
TextSentencer_T9 875-890 Sentence denotes EXPERT OPINION:
T9 875-890 Sentence denotes EXPERT OPINION:
TextSentencer_T10 891-1037 Sentence denotes Many multitargeted inhibitors which crossreact with RET have been developed and investigated in clinical trials targeting many cancer indications.
T10 891-1037 Sentence denotes Many multitargeted inhibitors which crossreact with RET have been developed and investigated in clinical trials targeting many cancer indications.
TextSentencer_T11 1038-1173 Sentence denotes In particular, VEGFR/PDGFR inhibitors, widely explored as antiangiogenics, have been intensively studied in thyroid carcinoma patients.
T11 1038-1173 Sentence denotes In particular, VEGFR/PDGFR inhibitors, widely explored as antiangiogenics, have been intensively studied in thyroid carcinoma patients.
TextSentencer_T12 1174-1384 Sentence denotes Notwithstanding the efficacy observed with such agents, their common clinical activity in thyroid carcinoma is of short duration and includes frequent and severe side effects, limiting their therapeutic action.
T12 1174-1384 Sentence denotes Notwithstanding the efficacy observed with such agents, their common clinical activity in thyroid carcinoma is of short duration and includes frequent and severe side effects, limiting their therapeutic action.
TextSentencer_T13 1385-1490 Sentence denotes These findings are discussed and the need for improved, more specific RET-targeting drugs is highlighted.
T13 1385-1490 Sentence denotes These findings are discussed and the need for improved, more specific RET-targeting drugs is highlighted.