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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-57 Sentence denotes Overexpression of Sulf2 in idiopathic pulmonary fibrosis.
T1 0-57 Sentence denotes Overexpression of Sulf2 in idiopathic pulmonary fibrosis.
T1 0-57 Sentence denotes Overexpression of Sulf2 in idiopathic pulmonary fibrosis.
TextSentencer_T2 58-421 Sentence denotes Previously, we have shown that heparan sulfate (HS) 6-O-endosulfatase 1 (Sulf1) is a transforming growth factor-β1 (TGF-β1)-responsive gene in normal human lung fibroblasts and functions as a negative feedback regulator of TGF-β1 and that TGF-β1 induces the expression of Sulf1 as well as that of the closely related Sulf2 in a murine model of pulmonary fibrosis.
T2 58-421 Sentence denotes Previously, we have shown that heparan sulfate (HS) 6-O-endosulfatase 1 (Sulf1) is a transforming growth factor-β1 (TGF-β1)-responsive gene in normal human lung fibroblasts and functions as a negative feedback regulator of TGF-β1 and that TGF-β1 induces the expression of Sulf1 as well as that of the closely related Sulf2 in a murine model of pulmonary fibrosis.
T2 58-421 Sentence denotes Previously, we have shown that heparan sulfate (HS) 6-O-endosulfatase 1 (Sulf1) is a transforming growth factor-β1 (TGF-β1)-responsive gene in normal human lung fibroblasts and functions as a negative feedback regulator of TGF-β1 and that TGF-β1 induces the expression of Sulf1 as well as that of the closely related Sulf2 in a murine model of pulmonary fibrosis.
TextSentencer_T3 422-541 Sentence denotes In this study, we focused on the role of Sulf2 in modulating TGF-β1 function and the development of pulmonary fibrosis.
T3 422-541 Sentence denotes In this study, we focused on the role of Sulf2 in modulating TGF-β1 function and the development of pulmonary fibrosis.
T3 422-541 Sentence denotes In this study, we focused on the role of Sulf2 in modulating TGF-β1 function and the development of pulmonary fibrosis.
TextSentencer_T4 542-769 Sentence denotes We found that Sulf2 mRNA was overexpressed in lung samples from human patients with idiopathic pulmonary fibrosis (IPF), and Sulf2 protein was specifically localized to the hyperplastic type II alveolar epithelial cells (AECs).
T4 542-769 Sentence denotes We found that Sulf2 mRNA was overexpressed in lung samples from human patients with idiopathic pulmonary fibrosis (IPF), and Sulf2 protein was specifically localized to the hyperplastic type II alveolar epithelial cells (AECs).
T4 542-769 Sentence denotes We found that Sulf2 mRNA was overexpressed in lung samples from human patients with idiopathic pulmonary fibrosis (IPF), and Sulf2 protein was specifically localized to the hyperplastic type II alveolar epithelial cells (AECs).
TextSentencer_T5 770-936 Sentence denotes In vitro, TGF-β1 induced the expression of Sulf2 with accompanied HS 6-O-desulfation in A549 cells, adenocarcinoma cells derived from the type II alveolar epithelium.
T5 770-936 Sentence denotes In vitro, TGF-β1 induced the expression of Sulf2 with accompanied HS 6-O-desulfation in A549 cells, adenocarcinoma cells derived from the type II alveolar epithelium.
T5 770-936 Sentence denotes In vitro, TGF-β1 induced the expression of Sulf2 with accompanied HS 6-O-desulfation in A549 cells, adenocarcinoma cells derived from the type II alveolar epithelium.
TextSentencer_T6 937-1184 Sentence denotes Using small interference RNA to block Sulf2 expression, we observed a biphasic TGF-β1 response with early enhanced Smad activation, but eventually reduced TGF-β1 target gene expression in Sulf2 knockdown A549 cells compared with the control cells.
T6 937-1184 Sentence denotes Using small interference RNA to block Sulf2 expression, we observed a biphasic TGF-β1 response with early enhanced Smad activation, but eventually reduced TGF-β1 target gene expression in Sulf2 knockdown A549 cells compared with the control cells.
T6 937-1184 Sentence denotes Using small interference RNA to block Sulf2 expression, we observed a biphasic TGF-β1 response with early enhanced Smad activation, but eventually reduced TGF-β1 target gene expression in Sulf2 knockdown A549 cells compared with the control cells.
TextSentencer_T7 1185-1309 Sentence denotes To study the role of Sulf2 in normal type II AECs, we isolated primary type II cells from wild-type and Sulf2 knockout mice.
T7 1185-1309 Sentence denotes To study the role of Sulf2 in normal type II AECs, we isolated primary type II cells from wild-type and Sulf2 knockout mice.
T7 1185-1309 Sentence denotes To study the role of Sulf2 in normal type II AECs, we isolated primary type II cells from wild-type and Sulf2 knockout mice.
TextSentencer_T8 1310-1465 Sentence denotes We observed enhanced Smad activation as well as enhanced TGF-β1 target gene expression in Sulf2 knockout type II AECs compared with wild-type type II AECs.
T8 1310-1465 Sentence denotes We observed enhanced Smad activation as well as enhanced TGF-β1 target gene expression in Sulf2 knockout type II AECs compared with wild-type type II AECs.
T8 1310-1465 Sentence denotes We observed enhanced Smad activation as well as enhanced TGF-β1 target gene expression in Sulf2 knockout type II AECs compared with wild-type type II AECs.
TextSentencer_T9 1466-1578 Sentence denotes In conclusion, Sulf2 is overexpressed in IPF and may play a role in regulating TGF-β1 signaling in type II AECs.
T9 1466-1578 Sentence denotes In conclusion, Sulf2 is overexpressed in IPF and may play a role in regulating TGF-β1 signaling in type II AECs.
T9 1466-1578 Sentence denotes In conclusion, Sulf2 is overexpressed in IPF and may play a role in regulating TGF-β1 signaling in type II AECs.