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PubMed:23275522 JSONTXT 43 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-108 Sentence denotes Cyclooxygenase-2 enzyme induces the expression of the α-2,3-sialyltransferase-3 (ST3Gal-I) in breast cancer.
T2 109-172 Sentence denotes Aberrant glycosylation is a common feature of malignant change.
T3 173-390 Sentence denotes Changes in mucin-type O-linked glycosylation in breast cancer can result in the expression of truncated core 1-based sialylated glycans rather than the core 2-based glycans observed in normal mammary epithelium cells.
T4 391-540 Sentence denotes This has been shown, in part, to be due to changes in the expression of glycosyltransferases, including the up-regulation of some sialyltransferases.
T5 541-869 Sentence denotes Using the breast cancer cell line T47D, we have shown that PGE2, one of the final products of the cyclooxygenase-2 (COX-2) pathway, can induce the mRNA expression of the sialyltransferase α-2,3-sialyltransferase-3 (ST3Gal-I), resulting in increased sialyltransferase activity, demonstrated by a reduction in PNA lectin staining.
T6 870-1069 Sentence denotes Induction of COX-2 in the MDA-MB-231 breast cancer cell line also results in the increased expression of ST3Gal-I, leading to increased sialylation of the substrate of ST3Gal-I, core 1 Galβ1,3GalNAc.
T7 1070-1158 Sentence denotes This effect on sialylation could be reversed by the selective COX-2 inhibitor celecoxib.
T8 1159-1312 Sentence denotes The use of siRNA to knock down COX-2 and overexpression of COX-2 in MDA-MD-231 cells confirmed the involvement of COX-2 in the up-regulation of ST3Gal-I.
T9 1313-1458 Sentence denotes Moreover, analysis of the expression of ST3Gal-I and COX-2 by 74 primary breast cancers showed a significant correlation between the two enzymes.
T10 1459-1601 Sentence denotes COX-2 expression has been associated with a number of tumors, including breast cancer, where its expression is associated with poor prognoses.
T11 1602-1812 Sentence denotes Thus, these results suggest the intriguing possibility that some of the malignant characteristics associated with COX-2 expression may be via the influence that COX-2 exerts on the glycosylation of tumor cells.