> top > projects > sentences > docs > PubMed:23246576 > annotations
sentences Home  

PubMed:23246576 JSONTXT 25 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-143 Sentence denotes The radio-sensitizing effect of xanthohumol is mediated by STAT3 and EGFR suppression in doxorubicin-resistant MCF-7 human breast cancer cells.
T1 0-143 Sentence denotes The radio-sensitizing effect of xanthohumol is mediated by STAT3 and EGFR suppression in doxorubicin-resistant MCF-7 human breast cancer cells.
TextSentencer_T2 144-155 Sentence denotes BACKGROUND:
T2 144-155 Sentence denotes BACKGROUND:
TextSentencer_T3 156-238 Sentence denotes Chemotherapeutic drug resistance remains a clinical obstacle in cancer management.
T3 156-238 Sentence denotes Chemotherapeutic drug resistance remains a clinical obstacle in cancer management.
TextSentencer_T4 239-371 Sentence denotes Drug-resistant cancer cells usually exhibit cross-resistance to ionizing radiation, which has devastating consequences for patients.
T4 239-371 Sentence denotes Drug-resistant cancer cells usually exhibit cross-resistance to ionizing radiation, which has devastating consequences for patients.
TextSentencer_T5 372-545 Sentence denotes With a better understanding of the molecular mechanisms, it will be possible to develop strategies to overcome this cross-resistance and to increase therapeutic sensitivity.
T5 372-545 Sentence denotes With a better understanding of the molecular mechanisms, it will be possible to develop strategies to overcome this cross-resistance and to increase therapeutic sensitivity.
TextSentencer_T6 546-554 Sentence denotes METHODS:
T6 546-554 Sentence denotes METHODS:
TextSentencer_T7 555-784 Sentence denotes Natural and synthetic flavonoid compounds including xanthohumol, the principal flavonoid in hops, were investigated for its radio-sensitizing activity on human breast cancer MCF-7 and adriamycin-resistant MCF-7 (MCF-7/ADR) cells.
T7 555-784 Sentence denotes Natural and synthetic flavonoid compounds including xanthohumol, the principal flavonoid in hops, were investigated for its radio-sensitizing activity on human breast cancer MCF-7 and adriamycin-resistant MCF-7 (MCF-7/ADR) cells.
TextSentencer_T8 785-903 Sentence denotes Chemo-sensitizing or radio-sensitizing effect was analyzed by tetrazolium-based colorimetric assay and flow cytometry.
T8 785-903 Sentence denotes Chemo-sensitizing or radio-sensitizing effect was analyzed by tetrazolium-based colorimetric assay and flow cytometry.
TextSentencer_T9 904-1078 Sentence denotes Western blot analysis, confocal microscopy, gene silencing with siRNA transfection and luciferase reporter gene assay were performed to examine signaling molecule activation.
T9 904-1078 Sentence denotes Western blot analysis, confocal microscopy, gene silencing with siRNA transfection and luciferase reporter gene assay were performed to examine signaling molecule activation.
TextSentencer_T10 1079-1087 Sentence denotes RESULTS:
T10 1079-1087 Sentence denotes RESULTS:
TextSentencer_T11 1088-1259 Sentence denotes Among the tested flavonoid compounds, pretreatment of the cells with xanthohumol significantly sensitized MCF-7/ADR cells to the radiation treatment by inducing apoptosis.
T11 1088-1259 Sentence denotes Among the tested flavonoid compounds, pretreatment of the cells with xanthohumol significantly sensitized MCF-7/ADR cells to the radiation treatment by inducing apoptosis.
TextSentencer_T12 1260-1390 Sentence denotes In MCF-7/ADR cells, treatment with xanthohumol alone or with gamma-rays significantly decreased levels of anti-apoptotic proteins.
T12 1260-1390 Sentence denotes In MCF-7/ADR cells, treatment with xanthohumol alone or with gamma-rays significantly decreased levels of anti-apoptotic proteins.
TextSentencer_T13 1391-1604 Sentence denotes Multi-drug resistance 1 (MDR1), epidermal growth factor receptor (EGFR) and signal transducer and activator of transcription 3 (STAT3) expression levels in MCF-7/ADR cells were suppressed by xanthohumol treatment.
T13 1391-1604 Sentence denotes Multi-drug resistance 1 (MDR1), epidermal growth factor receptor (EGFR) and signal transducer and activator of transcription 3 (STAT3) expression levels in MCF-7/ADR cells were suppressed by xanthohumol treatment.
TextSentencer_T14 1605-1691 Sentence denotes In addition, xanthohumol treatment increased death receptor (DR)-4 and DR5 expression.
T14 1605-1691 Sentence denotes In addition, xanthohumol treatment increased death receptor (DR)-4 and DR5 expression.
TextSentencer_T15 1692-1835 Sentence denotes The xanthohumol-induced changes of these resistance-related molecules in MCF-7/ADR cells were synergistically increased by gamma-ray treatment.
T15 1692-1835 Sentence denotes The xanthohumol-induced changes of these resistance-related molecules in MCF-7/ADR cells were synergistically increased by gamma-ray treatment.
TextSentencer_T16 1836-1848 Sentence denotes CONCLUSIONS:
T16 1836-1848 Sentence denotes CONCLUSIONS:
TextSentencer_T17 1849-1940 Sentence denotes Xanthohumol restored sensitivity of MCF-7/ADR cells to doxorubicin and radiation therapies.
T17 1849-1940 Sentence denotes Xanthohumol restored sensitivity of MCF-7/ADR cells to doxorubicin and radiation therapies.
TextSentencer_T18 1941-1962 Sentence denotes GENERAL SIGNIFICANCE:
T18 1941-1962 Sentence denotes GENERAL SIGNIFICANCE:
TextSentencer_T19 1963-2108 Sentence denotes Our results suggest that xanthohumol may be a potent chemo- and radio-sensitizer, and its actions are mediated through STAT3 and EGFR inhibition.
T19 1963-2108 Sentence denotes Our results suggest that xanthohumol may be a potent chemo- and radio-sensitizer, and its actions are mediated through STAT3 and EGFR inhibition.