> top > projects > sentences > docs > PubMed:23035012 > annotations
sentences Home  

PubMed:23035012 JSONTXT 67 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-155 Sentence denotes The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF-β secretion from monocytes/macrophages through the DAP12-Syk pathway.
T1 0-155 Sentence denotes The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF-β secretion from monocytes/macrophages through the DAP12-Syk pathway.
T1 0-155 Sentence denotes The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF-β secretion from monocytes/macrophages through the DAP12-Syk pathway.
TextSentencer_T2 156-396 Sentence denotes We previously demonstrated that Siglec-15, a member of the Siglec family of glycan-recognition proteins, is expressed on a subset of macrophages and preferentially recognizes the sialyl-Tn (sTn) antigen, a tumor-associated glycan structure.
T2 156-396 Sentence denotes We previously demonstrated that Siglec-15, a member of the Siglec family of glycan-recognition proteins, is expressed on a subset of macrophages and preferentially recognizes the sialyl-Tn (sTn) antigen, a tumor-associated glycan structure.
T2 156-396 Sentence denotes We previously demonstrated that Siglec-15, a member of the Siglec family of glycan-recognition proteins, is expressed on a subset of macrophages and preferentially recognizes the sialyl-Tn (sTn) antigen, a tumor-associated glycan structure.
TextSentencer_T3 397-538 Sentence denotes In this study, we report on the biological significance of the Siglec-15-mediated interaction between monocytes/macrophages and cancer cells.
T3 397-538 Sentence denotes In this study, we report on the biological significance of the Siglec-15-mediated interaction between monocytes/macrophages and cancer cells.
T3 397-538 Sentence denotes In this study, we report on the biological significance of the Siglec-15-mediated interaction between monocytes/macrophages and cancer cells.
TextSentencer_T4 539-632 Sentence denotes Siglec-15 is expressed on tumor-associated macrophages (TAMs) in various human tumor tissues.
T4 539-632 Sentence denotes Siglec-15 is expressed on tumor-associated macrophages (TAMs) in various human tumor tissues.
T4 539-632 Sentence denotes Siglec-15 is expressed on tumor-associated macrophages (TAMs) in various human tumor tissues.
TextSentencer_T5 633-886 Sentence denotes We further demonstrated that its expression is substantially elevated in macrophage colony-stimulating factor-induced M2-like macrophages, which produced more transforming growth factor-β (TGF-β) in response to sTn-positive cells than to negative cells.
T5 633-886 Sentence denotes We further demonstrated that its expression is substantially elevated in macrophage colony-stimulating factor-induced M2-like macrophages, which produced more transforming growth factor-β (TGF-β) in response to sTn-positive cells than to negative cells.
T5 633-886 Sentence denotes We further demonstrated that its expression is substantially elevated in macrophage colony-stimulating factor-induced M2-like macrophages, which produced more transforming growth factor-β (TGF-β) in response to sTn-positive cells than to negative cells.
TextSentencer_T6 887-1215 Sentence denotes We designed a co-culture model of THP-1 (human monocytic leukemia) cells and H157 (human lung carcinoma) cells mimicking the interaction between monocytes/macrophages and cancer cells that recapitulated the enhanced TGF-β production in Siglec-15 expressing THP-1 cells by the cellular interaction with sTn expressing H157 cells.
T6 887-1215 Sentence denotes We designed a co-culture model of THP-1 (human monocytic leukemia) cells and H157 (human lung carcinoma) cells mimicking the interaction between monocytes/macrophages and cancer cells that recapitulated the enhanced TGF-β production in Siglec-15 expressing THP-1 cells by the cellular interaction with sTn expressing H157 cells.
T6 887-1215 Sentence denotes We designed a co-culture model of THP-1 (human monocytic leukemia) cells and H157 (human lung carcinoma) cells mimicking the interaction between monocytes/macrophages and cancer cells that recapitulated the enhanced TGF-β production in Siglec-15 expressing THP-1 cells by the cellular interaction with sTn expressing H157 cells.
TextSentencer_T7 1216-1324 Sentence denotes The enhanced TGF-β production required a direct interaction between the two cell lines through sialic acids.
T7 1216-1324 Sentence denotes The enhanced TGF-β production required a direct interaction between the two cell lines through sialic acids.
T7 1216-1324 Sentence denotes The enhanced TGF-β production required a direct interaction between the two cell lines through sialic acids.
TextSentencer_T8 1325-1529 Sentence denotes Siglec-15 associates with adaptor protein DNAX activation protein of 12 kDa (DAP12) at the binding determinant Lys(274) in the transmembrane domain and transduces a signal to spleen tyrosine kinase (Syk).
T8 1325-1529 Sentence denotes Siglec-15 associates with adaptor protein DNAX activation protein of 12 kDa (DAP12) at the binding determinant Lys(274) in the transmembrane domain and transduces a signal to spleen tyrosine kinase (Syk).
T8 1325-1529 Sentence denotes Siglec-15 associates with adaptor protein DNAX activation protein of 12 kDa (DAP12) at the binding determinant Lys(274) in the transmembrane domain and transduces a signal to spleen tyrosine kinase (Syk).
TextSentencer_T9 1530-1751 Sentence denotes The enhanced TGF-β secretion was significantly attenuated by Syk inhibitor treatment of THP-1 cells or by substitution of the Siglec-15 Lys(274) to Ala, which disrupts the molecular interaction between Siglec15 and DAP12.
T9 1530-1751 Sentence denotes The enhanced TGF-β secretion was significantly attenuated by Syk inhibitor treatment of THP-1 cells or by substitution of the Siglec-15 Lys(274) to Ala, which disrupts the molecular interaction between Siglec15 and DAP12.
T9 1530-1751 Sentence denotes The enhanced TGF-β secretion was significantly attenuated by Syk inhibitor treatment of THP-1 cells or by substitution of the Siglec-15 Lys(274) to Ala, which disrupts the molecular interaction between Siglec15 and DAP12.
TextSentencer_T10 1752-2040 Sentence denotes These findings indicate that Siglec-15 recognizes the tumoral sTn antigen and transduces a signal for enhanced TGF-β secretion in TAMs and further suggest that Siglec-15 on macrophages may contribute to tumor progression by the TGF-β-mediated modulation of intratumoral microenvironments.
T10 1752-2040 Sentence denotes These findings indicate that Siglec-15 recognizes the tumoral sTn antigen and transduces a signal for enhanced TGF-β secretion in TAMs and further suggest that Siglec-15 on macrophages may contribute to tumor progression by the TGF-β-mediated modulation of intratumoral microenvironments.
T10 1752-2040 Sentence denotes These findings indicate that Siglec-15 recognizes the tumoral sTn antigen and transduces a signal for enhanced TGF-β secretion in TAMs and further suggest that Siglec-15 on macrophages may contribute to tumor progression by the TGF-β-mediated modulation of intratumoral microenvironments.