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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-120 Sentence denotes Role of mismatch repair enzymes in GAA·TTC triplet-repeat expansion in Friedreich ataxia induced pluripotent stem cells.
T1 0-120 Sentence denotes Role of mismatch repair enzymes in GAA·TTC triplet-repeat expansion in Friedreich ataxia induced pluripotent stem cells.
TextSentencer_T2 121-269 Sentence denotes The genetic mutation in Friedreich ataxia (FRDA) is a hyperexpansion of the triplet-repeat sequence GAA·TTC within the first intron of the FXN gene.
T2 121-269 Sentence denotes The genetic mutation in Friedreich ataxia (FRDA) is a hyperexpansion of the triplet-repeat sequence GAA·TTC within the first intron of the FXN gene.
TextSentencer_T3 270-588 Sentence denotes Although yeast and reporter construct models for GAA·TTC triplet-repeat expansion have been reported, studies on FRDA pathogenesis and therapeutic development are limited by the availability of an appropriate cell model in which to study the mechanism of instability of the GAA·TTC triplet repeats in the human genome.
T3 270-588 Sentence denotes Although yeast and reporter construct models for GAA·TTC triplet-repeat expansion have been reported, studies on FRDA pathogenesis and therapeutic development are limited by the availability of an appropriate cell model in which to study the mechanism of instability of the GAA·TTC triplet repeats in the human genome.
TextSentencer_T4 589-764 Sentence denotes Herein, induced pluripotent stem cells (iPSCs) were generated from FRDA patient fibroblasts after transduction with the four transcription factors Oct4, Sox2, Klf4, and c-Myc.
T4 589-764 Sentence denotes Herein, induced pluripotent stem cells (iPSCs) were generated from FRDA patient fibroblasts after transduction with the four transcription factors Oct4, Sox2, Klf4, and c-Myc.
TextSentencer_T5 765-890 Sentence denotes These cells were differentiated into neurospheres and neuronal precursors in vitro, providing a valuable cell model for FRDA.
T5 765-890 Sentence denotes These cells were differentiated into neurospheres and neuronal precursors in vitro, providing a valuable cell model for FRDA.
TextSentencer_T6 891-1016 Sentence denotes During propagation of the iPSCs, GAA·TTC triplet repeats expanded at a rate of about two GAA·TTC triplet repeats/replication.
T6 891-1016 Sentence denotes During propagation of the iPSCs, GAA·TTC triplet repeats expanded at a rate of about two GAA·TTC triplet repeats/replication.
TextSentencer_T7 1017-1106 Sentence denotes However, GAA·TTC triplet repeats were stable in FRDA fibroblasts and neuronal stem cells.
T7 1017-1106 Sentence denotes However, GAA·TTC triplet repeats were stable in FRDA fibroblasts and neuronal stem cells.
TextSentencer_T8 1107-1348 Sentence denotes The mismatch repair enzymes MSH2, MSH3, and MSH6, implicated in repeat instability in other triplet-repeat diseases, were highly expressed in pluripotent stem cells compared with fibroblasts and neuronal stem cells and occupied FXN intron 1.
T8 1107-1348 Sentence denotes The mismatch repair enzymes MSH2, MSH3, and MSH6, implicated in repeat instability in other triplet-repeat diseases, were highly expressed in pluripotent stem cells compared with fibroblasts and neuronal stem cells and occupied FXN intron 1.
TextSentencer_T9 1349-1436 Sentence denotes In addition, shRNA silencing of MSH2 and MSH6 impeded GAA·TTC triplet-repeat expansion.
T9 1349-1436 Sentence denotes In addition, shRNA silencing of MSH2 and MSH6 impeded GAA·TTC triplet-repeat expansion.
TextSentencer_T10 1437-1599 Sentence denotes A specific pyrrole-imidazole polyamide targeting GAA·TTC triplet-repeat DNA partially blocked repeat expansion by displacing MSH2 from FXN intron 1 in FRDA iPSCs.
T10 1437-1599 Sentence denotes A specific pyrrole-imidazole polyamide targeting GAA·TTC triplet-repeat DNA partially blocked repeat expansion by displacing MSH2 from FXN intron 1 in FRDA iPSCs.
TextSentencer_T11 1600-1751 Sentence denotes These studies suggest that in FRDA, GAA·TTC triplet-repeat instability occurs in embryonic cells and involves the highly active mismatch repair system.
T11 1600-1751 Sentence denotes These studies suggest that in FRDA, GAA·TTC triplet-repeat instability occurs in embryonic cells and involves the highly active mismatch repair system.