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PubMed:22797576 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-111 Sentence denotes Simultaneous siRNA-mediated knockdown of antiapoptotic BCL2, Bcl-xL, XIAP and survivin in bladder cancer cells.
T1 0-111 Sentence denotes Simultaneous siRNA-mediated knockdown of antiapoptotic BCL2, Bcl-xL, XIAP and survivin in bladder cancer cells.
TextSentencer_T2 112-187 Sentence denotes Bladder cancer (BCa) represents the ninth most common malignancy worldwide.
T2 112-187 Sentence denotes Bladder cancer (BCa) represents the ninth most common malignancy worldwide.
TextSentencer_T3 188-317 Sentence denotes Despite intensive treatment with surgery and chemotherapy the prognosis for BCa patients particularly at advanced stages is poor.
T3 188-317 Sentence denotes Despite intensive treatment with surgery and chemotherapy the prognosis for BCa patients particularly at advanced stages is poor.
TextSentencer_T4 318-379 Sentence denotes The ability to evade apoptosis is a hallmark of cancer cells.
T4 318-379 Sentence denotes The ability to evade apoptosis is a hallmark of cancer cells.
TextSentencer_T5 380-612 Sentence denotes Since the antiapoptotic genes BCL2, Bcl-xL, XIAP and survivin are frequently upregulated in BCa tissues, their combined siRNA-mediated knockdown might be more potent in decreasing BCa growth than the single inhibition of one target.
T5 380-612 Sentence denotes Since the antiapoptotic genes BCL2, Bcl-xL, XIAP and survivin are frequently upregulated in BCa tissues, their combined siRNA-mediated knockdown might be more potent in decreasing BCa growth than the single inhibition of one target.
TextSentencer_T6 613-766 Sentence denotes Against each target two siRNAs were selected that specifically reduced the mRNA and protein levels of their appropriate target in EJ28 and J82 BCa cells.
T6 613-766 Sentence denotes Against each target two siRNAs were selected that specifically reduced the mRNA and protein levels of their appropriate target in EJ28 and J82 BCa cells.
TextSentencer_T7 767-912 Sentence denotes Inhibition of survivin provoked the strongest antiproliferative effect of all single target treatments, for example cell counts decreased by 50%.
T7 767-912 Sentence denotes Inhibition of survivin provoked the strongest antiproliferative effect of all single target treatments, for example cell counts decreased by 50%.
TextSentencer_T8 913-1119 Sentence denotes Simultaneous targeting of all four antiapoptotic genes downregulated expression levels of all targets and mediated significant reductions in cell viability and cell counts as well as induction of apoptosis.
T8 913-1119 Sentence denotes Simultaneous targeting of all four antiapoptotic genes downregulated expression levels of all targets and mediated significant reductions in cell viability and cell counts as well as induction of apoptosis.
TextSentencer_T9 1120-1275 Sentence denotes In EJ28 cells, combined knockdown of BCL2, Bcl-xL, XIAP and survivin caused a 2.5-fold enhancement in apoptosis rate and reduced cellular viability by 40%.
T9 1120-1275 Sentence denotes In EJ28 cells, combined knockdown of BCL2, Bcl-xL, XIAP and survivin caused a 2.5-fold enhancement in apoptosis rate and reduced cellular viability by 40%.
TextSentencer_T10 1276-1421 Sentence denotes Therefore, simultaneous knockdown of antiapoptotic BCL2, Bcl‑xL, XIAP and survivin may represent a promising treatment option for bladder cancer.
T10 1276-1421 Sentence denotes Therefore, simultaneous knockdown of antiapoptotic BCL2, Bcl‑xL, XIAP and survivin may represent a promising treatment option for bladder cancer.