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PubMed:22773839 JSONTXT 29 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-147 Sentence denotes Protein kinase Cα (PKCα) regulates p53 localization and melanoma cell survival downstream of integrin αv in three-dimensional collagen and in vivo.
T1 0-147 Sentence denotes Protein kinase Cα (PKCα) regulates p53 localization and melanoma cell survival downstream of integrin αv in three-dimensional collagen and in vivo.
TextSentencer_T2 148-219 Sentence denotes Protein kinase C α (PKCα) is overexpressed in numerous types of cancer.
T2 148-219 Sentence denotes Protein kinase C α (PKCα) is overexpressed in numerous types of cancer.
TextSentencer_T3 220-302 Sentence denotes Importantly, PKCα has been linked to metastasis of malignant melanoma in patients.
T3 220-302 Sentence denotes Importantly, PKCα has been linked to metastasis of malignant melanoma in patients.
TextSentencer_T4 303-397 Sentence denotes However, it has been unclear how PKCα may be regulated and how it exerts its role in melanoma.
T4 303-397 Sentence denotes However, it has been unclear how PKCα may be regulated and how it exerts its role in melanoma.
TextSentencer_T5 398-550 Sentence denotes Here, we identified a role for PKCα in melanoma cell survival in a three-dimensional collagen model mimicking the in vivo pathophysiology of the dermis.
T5 398-550 Sentence denotes Here, we identified a role for PKCα in melanoma cell survival in a three-dimensional collagen model mimicking the in vivo pathophysiology of the dermis.
TextSentencer_T6 551-730 Sentence denotes A pathway was identified that involved integrin αv-mediated up-regulation of PKCα and PKCα-dependent regulation of p53 localization, which was connected to melanoma cell survival.
T6 551-730 Sentence denotes A pathway was identified that involved integrin αv-mediated up-regulation of PKCα and PKCα-dependent regulation of p53 localization, which was connected to melanoma cell survival.
TextSentencer_T7 731-875 Sentence denotes Melanoma survival and growth in three-dimensional microenvironments requires the expression of integrin αv, which acts to suppress p53 activity.
T7 731-875 Sentence denotes Melanoma survival and growth in three-dimensional microenvironments requires the expression of integrin αv, which acts to suppress p53 activity.
TextSentencer_T8 876-1019 Sentence denotes Interestingly, microarray analysis revealed that PKCα was up-regulated by integrin αv in a three-dimensional microenvironment-dependent manner.
T8 876-1019 Sentence denotes Interestingly, microarray analysis revealed that PKCα was up-regulated by integrin αv in a three-dimensional microenvironment-dependent manner.
TextSentencer_T9 1020-1277 Sentence denotes Integrin αv was observed to promote a relocalization of endogenous p53 from the nucleus to the cytoplasm upon growth in three-dimensional collagen as well as in vivo, whereas stable knockdown of PKCα inhibited the integrin αv-mediated relocalization of p53.
T9 1020-1277 Sentence denotes Integrin αv was observed to promote a relocalization of endogenous p53 from the nucleus to the cytoplasm upon growth in three-dimensional collagen as well as in vivo, whereas stable knockdown of PKCα inhibited the integrin αv-mediated relocalization of p53.
TextSentencer_T10 1278-1410 Sentence denotes Importantly, knockdown of PKCα also promoted apoptosis in three-dimensional collagen and in vivo, resulting in reduced tumor growth.
T10 1278-1410 Sentence denotes Importantly, knockdown of PKCα also promoted apoptosis in three-dimensional collagen and in vivo, resulting in reduced tumor growth.
TextSentencer_T11 1411-1561 Sentence denotes This indicates that PKCα constitutes a crucial component of the integrin αv-mediated pathway(s) that promote p53 relocalization and melanoma survival.
T11 1411-1561 Sentence denotes This indicates that PKCα constitutes a crucial component of the integrin αv-mediated pathway(s) that promote p53 relocalization and melanoma survival.