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Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-160 Sentence denotes Hyaluronan synthase polymerizing activity and control of product size are discrete enzyme functions that can be uncoupled by mutagenesis of conserved cysteines.
T1 0-160 Sentence denotes Hyaluronan synthase polymerizing activity and control of product size are discrete enzyme functions that can be uncoupled by mutagenesis of conserved cysteines.
T1 0-160 Sentence denotes Hyaluronan synthase polymerizing activity and control of product size are discrete enzyme functions that can be uncoupled by mutagenesis of conserved cysteines.
TextSentencer_T2 161-319 Sentence denotes Streptococcus equisimilis hyaluronan (HA) synthase (SeHAS) contains four cysteines (C226, C262, C281 and C367) that are conserved in the mammalian HAS family.
T2 161-319 Sentence denotes Streptococcus equisimilis hyaluronan (HA) synthase (SeHAS) contains four cysteines (C226, C262, C281 and C367) that are conserved in the mammalian HAS family.
T2 161-319 Sentence denotes Streptococcus equisimilis hyaluronan (HA) synthase (SeHAS) contains four cysteines (C226, C262, C281 and C367) that are conserved in the mammalian HAS family.
TextSentencer_T3 320-608 Sentence denotes Previous studies of single Cys-to-Ser and all possible Cys-to-Ala mutants of SeHAS found that: the Cys-null mutant is active, Cys modification inhibits HAS activity and the conserved cysteines are clustered at the membrane-enzyme interface in substrate-binding sites (Kumari K, Weigel PH.
T3 320-608 Sentence denotes Previous studies of single Cys-to-Ser and all possible Cys-to-Ala mutants of SeHAS found that: the Cys-null mutant is active, Cys modification inhibits HAS activity and the conserved cysteines are clustered at the membrane-enzyme interface in substrate-binding sites (Kumari K, Weigel PH.
T3 320-608 Sentence denotes Previous studies of single Cys-to-Ser and all possible Cys-to-Ala mutants of SeHAS found that: the Cys-null mutant is active, Cys modification inhibits HAS activity and the conserved cysteines are clustered at the membrane-enzyme interface in substrate-binding sites (Kumari K, Weigel PH.
TextSentencer_T4 609-614 Sentence denotes 2005.
T4 609-614 Sentence denotes 2005.
T4 609-614 Sentence denotes 2005.
TextSentencer_T5 615-757 Sentence denotes Identification of a membrane-localized cysteine cluster near the substrate binding sites of the Streptococcus equisimilis hyaluronan synthase.
T5 615-757 Sentence denotes Identification of a membrane-localized cysteine cluster near the substrate binding sites of the Streptococcus equisimilis hyaluronan synthase.
T5 615-757 Sentence denotes Identification of a membrane-localized cysteine cluster near the substrate binding sites of the Streptococcus equisimilis hyaluronan synthase.
TextSentencer_T6 758-771 Sentence denotes Glycobiology.
T6 758-771 Sentence denotes Glycobiology.
T6 758-784 Sentence denotes Glycobiology. 15:529-539).
TextSentencer_T7 772-784 Sentence denotes 15:529-539).
T7 772-784 Sentence denotes 15:529-539).
TextSentencer_T8 785-1012 Sentence denotes We re-examined these Cys mutants using a single technique (size exclusion chromatography-multi-angle laser light scattering) that allows simultaneous assays on the same sample for both HA synthesis activity and HA product size.
T7 785-1012 Sentence denotes We re-examined these Cys mutants using a single technique (size exclusion chromatography-multi-angle laser light scattering) that allows simultaneous assays on the same sample for both HA synthesis activity and HA product size.
T8 785-1012 Sentence denotes We re-examined these Cys mutants using a single technique (size exclusion chromatography-multi-angle laser light scattering) that allows simultaneous assays on the same sample for both HA synthesis activity and HA product size.
TextSentencer_T9 1013-1155 Sentence denotes Among 18 mutants compared with wild type, 4 showed no change in either function and 3 showed changes in both (decreased activity and HA size).
T8 1013-1155 Sentence denotes Among 18 mutants compared with wild type, 4 showed no change in either function and 3 showed changes in both (decreased activity and HA size).
T9 1013-1155 Sentence denotes Among 18 mutants compared with wild type, 4 showed no change in either function and 3 showed changes in both (decreased activity and HA size).
TextSentencer_T10 1156-1287 Sentence denotes Only one of the two functions was altered in 11 other mutants, which showed either decreased polymerizing activity or product size.
T9 1156-1287 Sentence denotes Only one of the two functions was altered in 11 other mutants, which showed either decreased polymerizing activity or product size.
T10 1156-1287 Sentence denotes Only one of the two functions was altered in 11 other mutants, which showed either decreased polymerizing activity or product size.
TextSentencer_T11 1288-1368 Sentence denotes No mutants made larger HA, 8 made smaller HA and 10 showed no change in HA size.
T10 1288-1368 Sentence denotes No mutants made larger HA, 8 made smaller HA and 10 showed no change in HA size.
T11 1288-1368 Sentence denotes No mutants made larger HA, 8 made smaller HA and 10 showed no change in HA size.
TextSentencer_T12 1369-1437 Sentence denotes Nine mutants showed no change in activity and nine were less active.
T11 1369-1437 Sentence denotes Nine mutants showed no change in activity and nine were less active.
T12 1369-1437 Sentence denotes Nine mutants showed no change in activity and nine were less active.
TextSentencer_T13 1438-1574 Sentence denotes The mutants fell into four of nine possible groups in terms of changes in HA size or synthesis rate (i.e. none, increased or decreased).
T12 1438-1574 Sentence denotes The mutants fell into four of nine possible groups in terms of changes in HA size or synthesis rate (i.e. none, increased or decreased).
T13 1438-1574 Sentence denotes The mutants fell into four of nine possible groups in terms of changes in HA size or synthesis rate (i.e. none, increased or decreased).
TextSentencer_T14 1575-1681 Sentence denotes Specific Cys residues were associated with each mutant group and the pattern of effects on both functions.
T13 1575-1681 Sentence denotes Specific Cys residues were associated with each mutant group and the pattern of effects on both functions.
T14 1575-1681 Sentence denotes Specific Cys residues were associated with each mutant group and the pattern of effects on both functions.
TextSentencer_T15 1682-1897 Sentence denotes Thus, the four conserved Cys residues, individually and in specific combinations, influence the rate of sugar assembly by HAS and HA product size, but their participation in one function is independent of the other.
T14 1682-1897 Sentence denotes Thus, the four conserved Cys residues, individually and in specific combinations, influence the rate of sugar assembly by HAS and HA product size, but their participation in one function is independent of the other.
T15 1682-1897 Sentence denotes Thus, the four conserved Cys residues, individually and in specific combinations, influence the rate of sugar assembly by HAS and HA product size, but their participation in one function is independent of the other.