| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-98 |
Sentence |
denotes |
Variants of Toll-like receptor 4 predict cardiac recovery in patients with dilated cardiomyopathy. |
| T2 |
99-221 |
Sentence |
denotes |
The clinical course of patients with dilated cardiomyopathy (DCM) varies from cardiac recovery to end stage heart failure. |
| T3 |
222-274 |
Sentence |
denotes |
The etiology of this variability is largely unknown. |
| T4 |
275-451 |
Sentence |
denotes |
In this study, we investigated the impact of coding polymorphisms of the innate immune protein Toll-like receptor 4 (TLR4) on left ventricular performance in patients with DCM. |
| T5 |
452-592 |
Sentence |
denotes |
Two variants of TLR4 (rs4986790, TLR4 c.1187A→G, p.299D→G and rs4986791,TLR4 c.1487C→T, p.T399I) were investigated in 158 patients with DCM. |
| T6 |
593-704 |
Sentence |
denotes |
Other reasons for heart failure were excluded by coronary angiography, myocardial biopsy, and echocardiography. |
| T7 |
705-777 |
Sentence |
denotes |
Risk factors, age, gender, or treatment did not differ among the groups. |
| T8 |
778-1133 |
Sentence |
denotes |
At the follow-up evaluation (median 4.0-5.4 months), patients carrying the TLR4 wild type gene displayed cardiac recovery under intense medical heart failure therapy indexed by reduced left ventricular dilation, improved left ventricular ejection fraction, and reduced NT-probrain natriuretic peptide blood level when compared with the initial evaluation. |
| T9 |
1134-1457 |
Sentence |
denotes |
In contrast, patients carrying both the rs4986790 and the rs4986791 variant showed significantly reduced improvement of left ventricular ejection fraction (p = 0.006) and left ventricular dilation (p = 0.015) at the follow-up evaluation when compared with carriers of the wild type gene under the same treatment conditions. |
| T10 |
1458-1629 |
Sentence |
denotes |
In addition, NT-probrain natriuretic peptide level in carriers of both TLR4 variants did not change significantly at the follow up when compared with the first evaluation. |
| T11 |
1630-1807 |
Sentence |
denotes |
Among patients with DCM, the presence of the TLR4 variants rs4986790 and rs4986791 predicts impaired cardiac recovery independently of medical treatment or cardiac risk factors. |
