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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-102 Sentence denotes DNA damage induces NF-κB-dependent microRNA-21 up-regulation and promotes breast cancer cell invasion.
T1 0-102 Sentence denotes DNA damage induces NF-κB-dependent microRNA-21 up-regulation and promotes breast cancer cell invasion.
TextSentencer_T2 103-246 Sentence denotes NF-κB activation induced by genotoxic treatment in cancer cells has been associated with therapeutic resistance in multiple human malignancies.
T2 103-246 Sentence denotes NF-κB activation induced by genotoxic treatment in cancer cells has been associated with therapeutic resistance in multiple human malignancies.
TextSentencer_T3 247-359 Sentence denotes Therapeutic resistance also correlates with high metastatic potential in human cancers, including breast cancer.
T3 247-359 Sentence denotes Therapeutic resistance also correlates with high metastatic potential in human cancers, including breast cancer.
TextSentencer_T4 360-490 Sentence denotes Whether genotoxic treatment-activated NF-κB also contributes to cancer metastasis following radiation and chemotherapy is unclear.
T4 360-490 Sentence denotes Whether genotoxic treatment-activated NF-κB also contributes to cancer metastasis following radiation and chemotherapy is unclear.
TextSentencer_T5 491-608 Sentence denotes Here, we show that chemotherapeutic drug-induced NF-κB activation promotes breast cancer cell migration and invasion.
T5 491-608 Sentence denotes Here, we show that chemotherapeutic drug-induced NF-κB activation promotes breast cancer cell migration and invasion.
TextSentencer_T6 609-714 Sentence denotes The increased metastatic potential is dependent on IL-6 induction mediated by genotoxic NF-κB activation.
T6 609-714 Sentence denotes The increased metastatic potential is dependent on IL-6 induction mediated by genotoxic NF-κB activation.
TextSentencer_T7 715-989 Sentence denotes Moreover, genotoxic treatment also up-regulates oncogenic microRNA-21 (miR-21) expression through eliciting NF-κB recruitment to the miR-21 promoter region, where it cooperates with signal transducer and activator of transcription 3 (STAT3) to activate miR-21 transcription.
T7 715-989 Sentence denotes Moreover, genotoxic treatment also up-regulates oncogenic microRNA-21 (miR-21) expression through eliciting NF-κB recruitment to the miR-21 promoter region, where it cooperates with signal transducer and activator of transcription 3 (STAT3) to activate miR-21 transcription.
TextSentencer_T8 990-1140 Sentence denotes DNA damage-induced histone H3 phosphorylation via activated MSK1 creates an open chromatin structure for NF-κB/STAT3-driven transactivation of miR-21.
T8 990-1140 Sentence denotes DNA damage-induced histone H3 phosphorylation via activated MSK1 creates an open chromatin structure for NF-κB/STAT3-driven transactivation of miR-21.
TextSentencer_T9 1141-1273 Sentence denotes NF-κB-dependent IL-6 up-regulation is responsible for STAT3 activation and recruitment to the miR-21 promoter upon genotoxic stress.
T9 1141-1273 Sentence denotes NF-κB-dependent IL-6 up-regulation is responsible for STAT3 activation and recruitment to the miR-21 promoter upon genotoxic stress.
TextSentencer_T10 1274-1464 Sentence denotes Induction of miR-21 may enable cancer cells to elude DNA damage-induced apoptosis and enhance the metastatic potential of breast cancer cells through repressing expression of PTEN and PDCD4.
T10 1274-1464 Sentence denotes Induction of miR-21 may enable cancer cells to elude DNA damage-induced apoptosis and enhance the metastatic potential of breast cancer cells through repressing expression of PTEN and PDCD4.
TextSentencer_T11 1465-1714 Sentence denotes Our data support a critical role of DNA damage-induced NF-κB activation in promoting cancer metastasis following genotoxic treatment, and NF-κB-dependent miR-21 induction may contribute to both therapeutic resistance and metastasis in breast cancer.
T11 1465-1714 Sentence denotes Our data support a critical role of DNA damage-induced NF-κB activation in promoting cancer metastasis following genotoxic treatment, and NF-κB-dependent miR-21 induction may contribute to both therapeutic resistance and metastasis in breast cancer.