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PubMed:22522123 JSONTXT 37 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-96 Sentence denotes Proteomic and redox-proteomic analysis of berberine-induced cytotoxicity in breast cancer cells.
T1 0-96 Sentence denotes Proteomic and redox-proteomic analysis of berberine-induced cytotoxicity in breast cancer cells.
TextSentencer_T2 97-237 Sentence denotes Berberine is a natural product isolated from herbal plants such as Rhizoma coptidis which has been shown to have anti-neoplastic properties.
T2 97-237 Sentence denotes Berberine is a natural product isolated from herbal plants such as Rhizoma coptidis which has been shown to have anti-neoplastic properties.
TextSentencer_T3 238-326 Sentence denotes However, the effects of berberine on the behavior of breast cancers are largely unknown.
T3 238-326 Sentence denotes However, the effects of berberine on the behavior of breast cancers are largely unknown.
TextSentencer_T4 327-703 Sentence denotes To determine if berberine might be useful in the treatment of breast cancer and its cytotoxic mechanism, we analyzed the impact of berberine treatment on differential protein expression and redox regulation in human breast cancer cell line MCF-7 using lysine- and cysteine-labeling two-dimensional difference gel electrophoresis (2D-DIGE) combined with mass spectrometry (MS).
T4 327-703 Sentence denotes To determine if berberine might be useful in the treatment of breast cancer and its cytotoxic mechanism, we analyzed the impact of berberine treatment on differential protein expression and redox regulation in human breast cancer cell line MCF-7 using lysine- and cysteine-labeling two-dimensional difference gel electrophoresis (2D-DIGE) combined with mass spectrometry (MS).
TextSentencer_T5 704-1084 Sentence denotes This study demonstrated that 96 and 22 protein features were significantly changed in protein expression and thiol reactivity, respectively and revealed that berberine-induced cytotoxicity in breast cancer cells involves dysregulation of protein folding, proteolysis, redox regulation, protein trafficking, cell signaling, electron transport, metabolism and centrosomal structure.
T5 704-1084 Sentence denotes This study demonstrated that 96 and 22 protein features were significantly changed in protein expression and thiol reactivity, respectively and revealed that berberine-induced cytotoxicity in breast cancer cells involves dysregulation of protein folding, proteolysis, redox regulation, protein trafficking, cell signaling, electron transport, metabolism and centrosomal structure.
TextSentencer_T6 1085-1253 Sentence denotes Our work shows that this combined proteomic strategy provides a rapid method to study the molecular mechanisms of berberine-induced cytotoxicity in breast cancer cells.
T6 1085-1253 Sentence denotes Our work shows that this combined proteomic strategy provides a rapid method to study the molecular mechanisms of berberine-induced cytotoxicity in breast cancer cells.
TextSentencer_T7 1254-1360 Sentence denotes The identified targets may be useful for further evaluation as potential targets in breast cancer therapy.
T7 1254-1360 Sentence denotes The identified targets may be useful for further evaluation as potential targets in breast cancer therapy.