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PubMed:22507221 JSONTXT 14 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-129 Sentence denotes YC-1 exerts inhibitory effects on MDA-MB-468 breast cancer cells by targeting EGFR in vitro and in vivo under normoxic condition.
T1 0-129 Sentence denotes YC-1 exerts inhibitory effects on MDA-MB-468 breast cancer cells by targeting EGFR in vitro and in vivo under normoxic condition.
TextSentencer_T2 130-351 Sentence denotes 3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole (YC-1), the hypoxia-inducible factor-1 alpha (HIF-1α) inhibitor, suppresses tumor proliferation and metastasis by down-regulating HIF-1α expression under hypoxic conditions.
T2 130-351 Sentence denotes 3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole (YC-1), the hypoxia-inducible factor-1 alpha (HIF-1α) inhibitor, suppresses tumor proliferation and metastasis by down-regulating HIF-1α expression under hypoxic conditions.
TextSentencer_T3 352-465 Sentence denotes Our previous studies demonstrated that YC-1 inhibited breast cancer cell proliferation under normoxic conditions.
T3 352-465 Sentence denotes Our previous studies demonstrated that YC-1 inhibited breast cancer cell proliferation under normoxic conditions.
TextSentencer_T4 466-586 Sentence denotes In the current study, we investigated the targets of YC-1 and mechanism of its action in MDA-MB-468 breast cancer cells.
T4 466-586 Sentence denotes In the current study, we investigated the targets of YC-1 and mechanism of its action in MDA-MB-468 breast cancer cells.
TextSentencer_T5 587-713 Sentence denotes In the in vitro experiments, we found that YC-1 significantly inhibited MDA-MB-468 cell proliferation in normoxia and hypoxia.
T5 587-713 Sentence denotes In the in vitro experiments, we found that YC-1 significantly inhibited MDA-MB-468 cell proliferation in normoxia and hypoxia.
TextSentencer_T6 714-902 Sentence denotes Under normoxic conditions, YC-1 induced apoptosis of MDA-MB-468 cells and blocked cell cycle in the G1 phase, and these effects were possibly related to caspase 8, p21, and p27 expression.
T6 714-902 Sentence denotes Under normoxic conditions, YC-1 induced apoptosis of MDA-MB-468 cells and blocked cell cycle in the G1 phase, and these effects were possibly related to caspase 8, p21, and p27 expression.
TextSentencer_T7 903-1169 Sentence denotes RT-PCR and Western blotting results showed that YC-1 primarily inhibited HIF-1α at the mRNA and protein levels under hypoxic conditions, but suppressed the expression of epidermal growth factor receptor(EGFR) at the mRNA and protein levels under normoxic conditions.
T7 903-1169 Sentence denotes RT-PCR and Western blotting results showed that YC-1 primarily inhibited HIF-1α at the mRNA and protein levels under hypoxic conditions, but suppressed the expression of epidermal growth factor receptor(EGFR) at the mRNA and protein levels under normoxic conditions.
TextSentencer_T8 1170-1319 Sentence denotes In vivo, YC-1 prolonged survival, increased survival rate, decreased tumor size and metastasis rate, and inhibited tissue EGFR and HIF-1α expression.
T8 1170-1319 Sentence denotes In vivo, YC-1 prolonged survival, increased survival rate, decreased tumor size and metastasis rate, and inhibited tissue EGFR and HIF-1α expression.
TextSentencer_T9 1320-1375 Sentence denotes However, YC-1 exerted no obvious effect on body weight.
T9 1320-1375 Sentence denotes However, YC-1 exerted no obvious effect on body weight.
TextSentencer_T10 1376-1512 Sentence denotes These results indicate that YC-1 inhibits the proliferation of MDA-MB-468 cells by acting on multiple targets with minimal side effects.
T10 1376-1512 Sentence denotes These results indicate that YC-1 inhibits the proliferation of MDA-MB-468 cells by acting on multiple targets with minimal side effects.
TextSentencer_T11 1513-1569 Sentence denotes Thus, YC-1 is a promising target drug for breast cancer.
T11 1513-1569 Sentence denotes Thus, YC-1 is a promising target drug for breast cancer.