| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-109 |
Sentence |
denotes |
Tumor suppressors p53, p63TAα, p63TAy, p73α, and p73β use distinct pathways to repress telomerase expression. |
| T1 |
0-109 |
Sentence |
denotes |
Tumor suppressors p53, p63TAα, p63TAy, p73α, and p73β use distinct pathways to repress telomerase expression. |
| TextSentencer_T2 |
110-302 |
Sentence |
denotes |
The promoter of the telomerase catalytic subunit (TERT) is subject to tight regulation and remains repressed in somatic cells to ensure their limited life span and to prevent tumor initiation. |
| T2 |
110-302 |
Sentence |
denotes |
The promoter of the telomerase catalytic subunit (TERT) is subject to tight regulation and remains repressed in somatic cells to ensure their limited life span and to prevent tumor initiation. |
| TextSentencer_T3 |
303-414 |
Sentence |
denotes |
Here we report that the hTERT promoter is strongly repressed by p53 and the related family members p63 and p73. |
| T3 |
303-414 |
Sentence |
denotes |
Here we report that the hTERT promoter is strongly repressed by p53 and the related family members p63 and p73. |
| TextSentencer_T4 |
415-605 |
Sentence |
denotes |
We found that p53-mediated repression was different in human and mouse cells and occurred through p53-dependent transcription inhibition of c-Myc or through E-box/E2F pathways, respectively. |
| T4 |
415-605 |
Sentence |
denotes |
We found that p53-mediated repression was different in human and mouse cells and occurred through p53-dependent transcription inhibition of c-Myc or through E-box/E2F pathways, respectively. |
| TextSentencer_T5 |
606-722 |
Sentence |
denotes |
Although p63TAα-mediated repression occurred through SP1, p63TAy-mediated repression occurred through E2F signaling. |
| T5 |
606-722 |
Sentence |
denotes |
Although p63TAα-mediated repression occurred through SP1, p63TAy-mediated repression occurred through E2F signaling. |
| TextSentencer_T6 |
723-791 |
Sentence |
denotes |
Finally, p73α- and p73β-mediated repression occurred through NF-YB2. |
| T6 |
723-791 |
Sentence |
denotes |
Finally, p73α- and p73β-mediated repression occurred through NF-YB2. |
| TextSentencer_T7 |
792-924 |
Sentence |
denotes |
Our results show a complex multifactorial mechanism used by p53 and its family members to keep hTERT expression under tight control. |
| T7 |
792-924 |
Sentence |
denotes |
Our results show a complex multifactorial mechanism used by p53 and its family members to keep hTERT expression under tight control. |