| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-110 |
Sentence |
denotes |
Hypersialylated type-I lactosamine-containing N-glycans found in Artiodactyla sera are potential xenoantigens. |
| T1 |
0-110 |
Sentence |
denotes |
Hypersialylated type-I lactosamine-containing N-glycans found in Artiodactyla sera are potential xenoantigens. |
| T1 |
0-110 |
Sentence |
denotes |
Hypersialylated type-I lactosamine-containing N-glycans found in Artiodactyla sera are potential xenoantigens. |
| TextSentencer_T2 |
111-201 |
Sentence |
denotes |
There is increasing interest in biologics, i.e. human-originated biological pharmaceutics. |
| T2 |
111-201 |
Sentence |
denotes |
There is increasing interest in biologics, i.e. human-originated biological pharmaceutics. |
| T2 |
111-201 |
Sentence |
denotes |
There is increasing interest in biologics, i.e. human-originated biological pharmaceutics. |
| TextSentencer_T3 |
202-482 |
Sentence |
denotes |
Most of the protein drugs developed so far, such as immunoglobulins and erythropoietin, are secreted glycoproteins; as a result, any non-human-type glycans, such as αGal and NeuGc, derived from animal cells and sera must be removed to circumvent undesirable immunogenic reactions. |
| T3 |
202-482 |
Sentence |
denotes |
Most of the protein drugs developed so far, such as immunoglobulins and erythropoietin, are secreted glycoproteins; as a result, any non-human-type glycans, such as αGal and NeuGc, derived from animal cells and sera must be removed to circumvent undesirable immunogenic reactions. |
| T3 |
202-482 |
Sentence |
denotes |
Most of the protein drugs developed so far, such as immunoglobulins and erythropoietin, are secreted glycoproteins; as a result, any non-human-type glycans, such as αGal and NeuGc, derived from animal cells and sera must be removed to circumvent undesirable immunogenic reactions. |
| TextSentencer_T4 |
483-594 |
Sentence |
denotes |
In this study, we made an extensive search for potential xenoantigenic glycans among a panel of mammalian sera. |
| T4 |
483-594 |
Sentence |
denotes |
In this study, we made an extensive search for potential xenoantigenic glycans among a panel of mammalian sera. |
| T4 |
483-594 |
Sentence |
denotes |
In this study, we made an extensive search for potential xenoantigenic glycans among a panel of mammalian sera. |
| TextSentencer_T5 |
595-886 |
Sentence |
denotes |
As a result, sera belonging to the order Artiodactyla, i.e. bovine, lamb and goat sera, were found to contain substantial amounts of hypersialylated biantennary glycans closely associated with a type-I lactosamine structure containing a unique tetrasaccharide, Siaα2-3Galβ1-3(Siaα2-6)GlcNAc. |
| T5 |
595-886 |
Sentence |
denotes |
As a result, sera belonging to the order Artiodactyla, i.e. bovine, lamb and goat sera, were found to contain substantial amounts of hypersialylated biantennary glycans closely associated with a type-I lactosamine structure containing a unique tetrasaccharide, Siaα2-3Galβ1-3(Siaα2-6)GlcNAc. |
| T5 |
595-886 |
Sentence |
denotes |
As a result, sera belonging to the order Artiodactyla, i.e. bovine, lamb and goat sera, were found to contain substantial amounts of hypersialylated biantennary glycans closely associated with a type-I lactosamine structure containing a unique tetrasaccharide, Siaα2-3Galβ1-3(Siaα2-6)GlcNAc. |
| TextSentencer_T6 |
887-1048 |
Sentence |
denotes |
In all three Artiodactyla sera, the most abundant structure was Siaα2-3Galβ1-3(Siaα2-6)GlcNAcβ1-2Manα1-3[Siaα2-6Galβ1-4GlcNAcβ1-2Manα1-6]Manβ1-4GlcNAcβ1-4GlcNAc. |
| T6 |
887-1048 |
Sentence |
denotes |
In all three Artiodactyla sera, the most abundant structure was Siaα2-3Galβ1-3(Siaα2-6)GlcNAcβ1-2Manα1-3[Siaα2-6Galβ1-4GlcNAcβ1-2Manα1-6]Manβ1-4GlcNAcβ1-4GlcNAc. |
| T6 |
887-1048 |
Sentence |
denotes |
In all three Artiodactyla sera, the most abundant structure was Siaα2-3Galβ1-3(Siaα2-6)GlcNAcβ1-2Manα1-3[Siaα2-6Galβ1-4GlcNAcβ1-2Manα1-6]Manβ1-4GlcNAcβ1-4GlcNAc. |
| TextSentencer_T7 |
1049-1244 |
Sentence |
denotes |
A dually hypersialylated biantennary structure, Siaα2-3Galβ1-3(Siaα2-6)GlcNAcβ1-2Manα1-3[Siaα2-3Galβ1-3(Siaα2-6)GlcNAcβ1-2Manα1-6]Manβ1-4GlcNAcβ1-4GlcNAc, was also abundant (10%) in bovine serum. |
| T7 |
1049-1244 |
Sentence |
denotes |
A dually hypersialylated biantennary structure, Siaα2-3Galβ1-3(Siaα2-6)GlcNAcβ1-2Manα1-3[Siaα2-3Galβ1-3(Siaα2-6)GlcNAcβ1-2Manα1-6]Manβ1-4GlcNAcβ1-4GlcNAc, was also abundant (10%) in bovine serum. |
| T7 |
1049-1244 |
Sentence |
denotes |
A dually hypersialylated biantennary structure, Siaα2-3Galβ1-3(Siaα2-6)GlcNAcβ1-2Manα1-3[Siaα2-3Galβ1-3(Siaα2-6)GlcNAcβ1-2Manα1-6]Manβ1-4GlcNAcβ1-4GlcNAc, was also abundant (10%) in bovine serum. |
| TextSentencer_T8 |
1245-1377 |
Sentence |
denotes |
The amount of hypersialylated glycans among total sialylated glycans was 46, 26 and 23% in bovine, lamb and goat sera, respectively. |
| T8 |
1245-1377 |
Sentence |
denotes |
The amount of hypersialylated glycans among total sialylated glycans was 46, 26 and 23% in bovine, lamb and goat sera, respectively. |
| T8 |
1245-1377 |
Sentence |
denotes |
The amount of hypersialylated glycans among total sialylated glycans was 46, 26 and 23% in bovine, lamb and goat sera, respectively. |
| TextSentencer_T9 |
1378-1480 |
Sentence |
denotes |
On the other hand, such structures could not be detected in the sera of other animals including human. |
| T9 |
1378-1480 |
Sentence |
denotes |
On the other hand, such structures could not be detected in the sera of other animals including human. |
| T9 |
1378-1480 |
Sentence |
denotes |
On the other hand, such structures could not be detected in the sera of other animals including human. |
| TextSentencer_T10 |
1481-1786 |
Sentence |
denotes |
The biological functions and the immunogenicity of the hypersialylated glycans in these animals remain to be elucidated; however, it is worth noting that glycoproteins biosynthesized from Artiodactyla cells and those contaminated with bovine serum might enhance undesirable antigenicity in human patients. |
| T10 |
1481-1786 |
Sentence |
denotes |
The biological functions and the immunogenicity of the hypersialylated glycans in these animals remain to be elucidated; however, it is worth noting that glycoproteins biosynthesized from Artiodactyla cells and those contaminated with bovine serum might enhance undesirable antigenicity in human patients. |
| T10 |
1481-1786 |
Sentence |
denotes |
The biological functions and the immunogenicity of the hypersialylated glycans in these animals remain to be elucidated; however, it is worth noting that glycoproteins biosynthesized from Artiodactyla cells and those contaminated with bovine serum might enhance undesirable antigenicity in human patients. |