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PubMed:22474291 JSONTXT 25 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-157 Sentence denotes Identification of the Bombyx red egg gene reveals involvement of a novel transporter family gene in late steps of the insect ommochrome biosynthesis pathway.
T2 158-266 Sentence denotes Ommochromes are one of the major pigments involved in coloration of eggs, eyes, and body surface of insects.
T3 267-378 Sentence denotes However, the molecular mechanisms of the final steps of ommochrome pigment synthesis have been largely unknown.
T4 379-493 Sentence denotes The eggs of the silkworm Bombyx mori contain a mixture of ommochrome pigments, and exhibit a brownish lilac color.
T5 494-730 Sentence denotes The recessive homozygous of egg and eye color mutant, red egg (re), whose eggs display a pale orange color instead of normal dark coloration, has been long suggested to have a defect in the biosynthesis of the final ommochrome pigments.
T6 731-848 Sentence denotes Here, we identify the gene responsible for the re locus by positional cloning, mutant analysis, and RNAi experiments.
T7 849-1214 Sentence denotes In the re mutants, we found that a 541-bp transposable element is inserted into the ORF of BGIBMGA003497-1 (Bm-re) encoding a novel member of a major facilitator superfamily transporter, causing disruption of the splicing of exon 9, resulting in two aberrant transcripts with frameshifts yielding nonfunctional proteins lacking the C-terminal transmembrane domains.
T8 1215-1290 Sentence denotes Bm-re function in pigmentation was confirmed by embryonic RNAi experiments.
T9 1291-1577 Sentence denotes Homologs of the Bm-re gene were found in all insect genomes sequenced at present, except for 12 sequenced Drosophila genomes, which seemed to correlate with the previous studies that have demonstrated that eye ommochrome composition is different from other insects in several Dipterans.
T10 1578-1808 Sentence denotes Knockdown of the Bm-re homolog by RNAi in the red flour beetle Tribolium castaneum caused adult compound eye coloration defects, indicating a conserved role in ommochrome pigment biosynthesis at least among holometabolous insects.