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PubMed:22460125 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-116 Sentence denotes Identification of ING4 (inhibitor of growth 4) as a modulator of docetaxel sensitivity in human lung adenocarcinoma.
T1 0-116 Sentence denotes Identification of ING4 (inhibitor of growth 4) as a modulator of docetaxel sensitivity in human lung adenocarcinoma.
TextSentencer_T2 117-199 Sentence denotes Resistance to docetaxel (DTX) usually occurs in patients with lung adenocarcinoma.
T2 117-199 Sentence denotes Resistance to docetaxel (DTX) usually occurs in patients with lung adenocarcinoma.
TextSentencer_T3 200-380 Sentence denotes To better elucidate the underlying molecular mechanisms involved in resistance to DTX-based chemotherapy, we established a DTX-resistant lung adenocarcinoma cell line (SPC-A1/DTX).
T3 200-380 Sentence denotes To better elucidate the underlying molecular mechanisms involved in resistance to DTX-based chemotherapy, we established a DTX-resistant lung adenocarcinoma cell line (SPC-A1/DTX).
TextSentencer_T4 381-492 Sentence denotes By gene array analysis, the expression of ING4 was found to be significantly downregulated in SPC-A1/DTX cells.
T4 381-492 Sentence denotes By gene array analysis, the expression of ING4 was found to be significantly downregulated in SPC-A1/DTX cells.
TextSentencer_T5 493-596 Sentence denotes Additionally, the decreased expression of the ING4 gene was induced upon DTX treatment of SPC-A1 cells.
T5 493-596 Sentence denotes Additionally, the decreased expression of the ING4 gene was induced upon DTX treatment of SPC-A1 cells.
TextSentencer_T6 597-913 Sentence denotes Overexpression of ING4 reverses DTX or paclitaxel resistance of DTX-resistant lung adenocarcinoma cells (SPC-A1/DTX or A549/Taxol) by inducing apoptosis enhancement and G₂/M arrest, and small interfering RNA-mediated ING4 knockdown renders DTX-sensitive lung adenocarcinoma cells more resistant to DTX or paclitaxel.
T6 597-913 Sentence denotes Overexpression of ING4 reverses DTX or paclitaxel resistance of DTX-resistant lung adenocarcinoma cells (SPC-A1/DTX or A549/Taxol) by inducing apoptosis enhancement and G₂/M arrest, and small interfering RNA-mediated ING4 knockdown renders DTX-sensitive lung adenocarcinoma cells more resistant to DTX or paclitaxel.
TextSentencer_T7 914-1008 Sentence denotes Also, overexpression of ING4 could enhance the in vivo sensitivity of SPC-A1/DTX cells to DTX.
T7 914-1008 Sentence denotes Also, overexpression of ING4 could enhance the in vivo sensitivity of SPC-A1/DTX cells to DTX.
TextSentencer_T8 1009-1193 Sentence denotes The phenotypical changes of SPC-A1/DTX cells induced by overexpression of ING4 might be associated with the decreased ratio of Bcl-2/Bax, which resulted in the activation of caspase-3.
T8 1009-1193 Sentence denotes The phenotypical changes of SPC-A1/DTX cells induced by overexpression of ING4 might be associated with the decreased ratio of Bcl-2/Bax, which resulted in the activation of caspase-3.
TextSentencer_T9 1194-1409 Sentence denotes The level of ING4 expression in tumors of nonresponding patients was significantly lower than that in those of responders, suggesting that the expression of ING4 was positively correlated with tumor response to DTX.
T9 1194-1409 Sentence denotes The level of ING4 expression in tumors of nonresponding patients was significantly lower than that in those of responders, suggesting that the expression of ING4 was positively correlated with tumor response to DTX.
TextSentencer_T10 1410-1520 Sentence denotes Our results provide the first evidence that ING4 might be essential for DTX resistance in lung adenocarcinoma.
T10 1410-1520 Sentence denotes Our results provide the first evidence that ING4 might be essential for DTX resistance in lung adenocarcinoma.
TextSentencer_T11 1521-1646 Sentence denotes Thus, ING4 will be a potential molecular target for overcoming resistance to DTX-based chemotherapies in lung adenocarcinoma.
T11 1521-1646 Sentence denotes Thus, ING4 will be a potential molecular target for overcoming resistance to DTX-based chemotherapies in lung adenocarcinoma.