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PubMed:22434778 JSONTXT 62 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-127 Sentence denotes Structural basis for carbohydrate-binding specificity--a comparative assessment of two engineered carbohydrate-binding modules.
T1 0-127 Sentence denotes Structural basis for carbohydrate-binding specificity--a comparative assessment of two engineered carbohydrate-binding modules.
T1 0-127 Sentence denotes Structural basis for carbohydrate-binding specificity--a comparative assessment of two engineered carbohydrate-binding modules.
TextSentencer_T2 128-280 Sentence denotes Detection, immobilization and purification of carbohydrates can be done using molecular probes that specifically bind to targeted carbohydrate epitopes.
T2 128-280 Sentence denotes Detection, immobilization and purification of carbohydrates can be done using molecular probes that specifically bind to targeted carbohydrate epitopes.
T2 128-280 Sentence denotes Detection, immobilization and purification of carbohydrates can be done using molecular probes that specifically bind to targeted carbohydrate epitopes.
TextSentencer_T3 281-453 Sentence denotes Carbohydrate-binding modules (CBMs) are discrete parts of carbohydrate-hydrolyzing enzymes that can be engineered to bind and detect specifically a number of carbohydrates.
T3 281-453 Sentence denotes Carbohydrate-binding modules (CBMs) are discrete parts of carbohydrate-hydrolyzing enzymes that can be engineered to bind and detect specifically a number of carbohydrates.
T3 281-453 Sentence denotes Carbohydrate-binding modules (CBMs) are discrete parts of carbohydrate-hydrolyzing enzymes that can be engineered to bind and detect specifically a number of carbohydrates.
TextSentencer_T4 454-627 Sentence denotes Design and engineering of CBMs have benefited greatly from structural studies that have helped us to decipher the basis for specificity in carbohydrate-protein interactions.
T4 454-627 Sentence denotes Design and engineering of CBMs have benefited greatly from structural studies that have helped us to decipher the basis for specificity in carbohydrate-protein interactions.
T4 454-627 Sentence denotes Design and engineering of CBMs have benefited greatly from structural studies that have helped us to decipher the basis for specificity in carbohydrate-protein interactions.
TextSentencer_T5 628-761 Sentence denotes However, more studies are needed to predict which modifications in a CBM would generate probes with predetermined binding properties.
T5 628-761 Sentence denotes However, more studies are needed to predict which modifications in a CBM would generate probes with predetermined binding properties.
T5 628-761 Sentence denotes However, more studies are needed to predict which modifications in a CBM would generate probes with predetermined binding properties.
TextSentencer_T6 762-1018 Sentence denotes In this report, we present the crystal structures of two highly related engineered CBMs with different binding specificity profiles: X-2, which is specific for xylans and the L110F mutant of X-2, which binds xyloglucans and β-glucans in addition to xylans.
T6 762-1018 Sentence denotes In this report, we present the crystal structures of two highly related engineered CBMs with different binding specificity profiles: X-2, which is specific for xylans and the L110F mutant of X-2, which binds xyloglucans and β-glucans in addition to xylans.
T6 762-1018 Sentence denotes In this report, we present the crystal structures of two highly related engineered CBMs with different binding specificity profiles: X-2, which is specific for xylans and the L110F mutant of X-2, which binds xyloglucans and β-glucans in addition to xylans.
TextSentencer_T7 1019-1186 Sentence denotes The structures of the modules were solved both in the apo form and complexed with oligomers of xylose, as well as with an oligomer of glucose in the case of X-2 L110F.
T7 1019-1186 Sentence denotes The structures of the modules were solved both in the apo form and complexed with oligomers of xylose, as well as with an oligomer of glucose in the case of X-2 L110F.
T7 1019-1186 Sentence denotes The structures of the modules were solved both in the apo form and complexed with oligomers of xylose, as well as with an oligomer of glucose in the case of X-2 L110F.
TextSentencer_T8 1187-1383 Sentence denotes The mutation, leucine to phenylalanine, converting the specific module into a cross-reactive one, introduces a crucial hydrogen-π interaction that allows the mutant to retain glucan-based ligands.
T8 1187-1383 Sentence denotes The mutation, leucine to phenylalanine, converting the specific module into a cross-reactive one, introduces a crucial hydrogen-π interaction that allows the mutant to retain glucan-based ligands.
T8 1187-1383 Sentence denotes The mutation, leucine to phenylalanine, converting the specific module into a cross-reactive one, introduces a crucial hydrogen-π interaction that allows the mutant to retain glucan-based ligands.
TextSentencer_T9 1384-1619 Sentence denotes The cross-reactivity of X-2 L110F is furthermore made possible by the plasticity of the protein, in particular, of residue R142, which permits accommodation of an extra hydroxymethyl group present in cellopentaose and not xylopentaose.
T9 1384-1619 Sentence denotes The cross-reactivity of X-2 L110F is furthermore made possible by the plasticity of the protein, in particular, of residue R142, which permits accommodation of an extra hydroxymethyl group present in cellopentaose and not xylopentaose.
T9 1384-1619 Sentence denotes The cross-reactivity of X-2 L110F is furthermore made possible by the plasticity of the protein, in particular, of residue R142, which permits accommodation of an extra hydroxymethyl group present in cellopentaose and not xylopentaose.
TextSentencer_T10 1620-1832 Sentence denotes Altogether, this study shows, in structural detail, altered protein-carbohydrate interactions that have high impact on the binding properties of a carbohydrate probe but are introduced through simple mutagenesis.
T10 1620-1832 Sentence denotes Altogether, this study shows, in structural detail, altered protein-carbohydrate interactions that have high impact on the binding properties of a carbohydrate probe but are introduced through simple mutagenesis.
T10 1620-1832 Sentence denotes Altogether, this study shows, in structural detail, altered protein-carbohydrate interactions that have high impact on the binding properties of a carbohydrate probe but are introduced through simple mutagenesis.