| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-128 |
Sentence |
denotes |
Apolipoprotein E3 (ApoE3) but not ApoE4 protects against synaptic loss through increased expression of protein kinase C epsilon. |
| T2 |
129-289 |
Sentence |
denotes |
Synaptic loss is the earliest pathological change in Alzheimer disease (AD) and is the pathological change most directly correlated with the degree of dementia. |
| T3 |
290-395 |
Sentence |
denotes |
ApoE4 is the major genetic risk factor for the age-dependent form of AD, which accounts for 95% of cases. |
| T4 |
396-597 |
Sentence |
denotes |
Here we show that in synaptic networks formed from primary hippocampal neurons in culture, apoE3, but not apoE4, prevents the loss of synaptic networks produced by amyloid β oligomers (amylospheroids). |
| T5 |
598-876 |
Sentence |
denotes |
Specific activators of PKCε, such as 8-(2-(2-pentyl-cyclopropylmethyl)-cyclopropyl)-octanoic acid methyl ester and bryostatin 1, protected against synaptic loss by amylospheroids, whereas PKCε inhibitors blocked this synaptic protection and also blocked the protection by apoE3. |
| T6 |
877-971 |
Sentence |
denotes |
Blocking LRP1, an apoE receptor on the neuronal membrane, also blocked the protection by apoE. |
| T7 |
972-1064 |
Sentence |
denotes |
ApoE3, but not apoE4, induced the synthesis of PKCε mRNA and expression of the PKCε protein. |
| T8 |
1065-1155 |
Sentence |
denotes |
Amyloid β specifically blocked the expression of PKCε but had no effect on other isoforms. |
| T9 |
1156-1274 |
Sentence |
denotes |
These results suggest that protection against synaptic loss by apoE is mediated by a novel intracellular PKCε pathway. |
| T10 |
1275-1397 |
Sentence |
denotes |
This apoE pathway may account for much of the protective effect of apoE and reduced risk for the age-dependent form of AD. |
| T11 |
1398-1482 |
Sentence |
denotes |
This finding supports the potential efficacy of newly developed therapeutics for AD. |
