> top > projects > sentences > docs > PubMed:22270009 > annotations
sentences Home  

PubMed:22270009 JSONTXT 44 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-91 Sentence denotes Proteomic analysis of human hepatoma cells expressing methionine adenosyltransferase I/III:
T1 0-91 Sentence denotes Proteomic analysis of human hepatoma cells expressing methionine adenosyltransferase I/III:
TextSentencer_T2 92-154 Sentence denotes Characterization of DDX3X as a target of S-adenosylmethionine.
T2 92-154 Sentence denotes Characterization of DDX3X as a target of S-adenosylmethionine.
TextSentencer_T3 155-267 Sentence denotes Methionine adenosyltransferase I/III (MATI/III) synthesizes S-adenosylmethionine (SAM) in quiescent hepatocytes.
T3 155-267 Sentence denotes Methionine adenosyltransferase I/III (MATI/III) synthesizes S-adenosylmethionine (SAM) in quiescent hepatocytes.
TextSentencer_T4 268-342 Sentence denotes Its activity is compromised in most liver diseases including liver cancer.
T4 268-342 Sentence denotes Its activity is compromised in most liver diseases including liver cancer.
TextSentencer_T5 343-475 Sentence denotes Since SAM is a driver of hepatocytes fate we have studied the effect of re-expressing MAT1A in hepatoma Huh7 cells using proteomics.
T5 343-475 Sentence denotes Since SAM is a driver of hepatocytes fate we have studied the effect of re-expressing MAT1A in hepatoma Huh7 cells using proteomics.
TextSentencer_T6 476-581 Sentence denotes MAT1A expression leads to SAM levels close to those found in quiescent hepatocytes and induced apoptosis.
T6 476-581 Sentence denotes MAT1A expression leads to SAM levels close to those found in quiescent hepatocytes and induced apoptosis.
TextSentencer_T7 582-807 Sentence denotes Normalization of intracellular SAM induced alteration of 128 proteins identified by 2D-DIGE and gel-free methods, accounting for deregulation of central cellular functions including apoptosis, cell proliferation and survival.
T7 582-807 Sentence denotes Normalization of intracellular SAM induced alteration of 128 proteins identified by 2D-DIGE and gel-free methods, accounting for deregulation of central cellular functions including apoptosis, cell proliferation and survival.
TextSentencer_T8 808-961 Sentence denotes Human Dead-box protein 3 (DDX3X), a RNA helicase regulating RNA splicing, export, transcription and translation was down-regulated upon MAT1A expression.
T8 808-961 Sentence denotes Human Dead-box protein 3 (DDX3X), a RNA helicase regulating RNA splicing, export, transcription and translation was down-regulated upon MAT1A expression.
TextSentencer_T9 962-1062 Sentence denotes Our data support the regulation of DDX3X levels by SAM in a concentration and time dependent manner.
T9 962-1062 Sentence denotes Our data support the regulation of DDX3X levels by SAM in a concentration and time dependent manner.
TextSentencer_T10 1063-1172 Sentence denotes Consistently, DDX3X arises as a primary target of SAM and a principal intermediate of its antitumoral effect.
T10 1063-1172 Sentence denotes Consistently, DDX3X arises as a primary target of SAM and a principal intermediate of its antitumoral effect.
TextSentencer_T11 1173-1532 Sentence denotes Based on the parallelism between SAM and DDX3X along the progression of liver disorders, and the results reported here, it is tempting to suggest that reduced SAM in the liver may lead to DDX3X up-regulation contributing to the pathogenic process and that replenishment of SAM might prove to have beneficial effects, at least in part by reducing DDX3X levels.
T11 1173-1532 Sentence denotes Based on the parallelism between SAM and DDX3X along the progression of liver disorders, and the results reported here, it is tempting to suggest that reduced SAM in the liver may lead to DDX3X up-regulation contributing to the pathogenic process and that replenishment of SAM might prove to have beneficial effects, at least in part by reducing DDX3X levels.
TextSentencer_T12 1533-1582 Sentence denotes This article is part of a Special Issue entitled:
T12 1533-1582 Sentence denotes This article is part of a Special Issue entitled:
TextSentencer_T13 1583-1594 Sentence denotes Proteomics:
T13 1583-1594 Sentence denotes Proteomics:
TextSentencer_T14 1595-1613 Sentence denotes The clinical link.
T14 1595-1613 Sentence denotes The clinical link.