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PubMed:22188495 JSONTXT 13 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-100 Sentence denotes A case of Werner syndrome without metabolic abnormality: implications for the early pathophysiology.
T1 0-100 Sentence denotes A case of Werner syndrome without metabolic abnormality: implications for the early pathophysiology.
TextSentencer_T2 101-211 Sentence denotes Werner syndrome (WS) is an autosomal recessive progeroid disorder caused by mutations in the WRN DNA helicase.
T2 101-211 Sentence denotes Werner syndrome (WS) is an autosomal recessive progeroid disorder caused by mutations in the WRN DNA helicase.
TextSentencer_T3 212-445 Sentence denotes It is characterized by the graying and loss of hair, juvenile cataracts, sclerosis and ulceration of skin, insulin-resistant diabetes mellitus, dyslipidemia, abdominal adiposity, osteoporosis, atherosclerosis, and malignant neoplasm.
T3 212-445 Sentence denotes It is characterized by the graying and loss of hair, juvenile cataracts, sclerosis and ulceration of skin, insulin-resistant diabetes mellitus, dyslipidemia, abdominal adiposity, osteoporosis, atherosclerosis, and malignant neoplasm.
TextSentencer_T4 446-574 Sentence denotes Patients are usually diagnosed in their 30s or 40s, but the early pathophysiology of the syndrome is still not fully understood.
T4 446-574 Sentence denotes Patients are usually diagnosed in their 30s or 40s, but the early pathophysiology of the syndrome is still not fully understood.
TextSentencer_T5 575-683 Sentence denotes Here we report a 29-year-old female patient who displayed cataracts, hair graying, and tendinous calcinosis.
T5 575-683 Sentence denotes Here we report a 29-year-old female patient who displayed cataracts, hair graying, and tendinous calcinosis.
TextSentencer_T6 684-715 Sentence denotes Her parents were first cousins.
T6 684-715 Sentence denotes Her parents were first cousins.
TextSentencer_T7 716-861 Sentence denotes Interestingly, the patient lacked the metabolic signs typical for WS, including glucose intolerance, dyslipidemia, and visceral fat accumulation.
T7 716-861 Sentence denotes Interestingly, the patient lacked the metabolic signs typical for WS, including glucose intolerance, dyslipidemia, and visceral fat accumulation.
TextSentencer_T8 862-947 Sentence denotes A hyperinsulinemic response at 30 min was observed in an oral glucose tolerance test.
T8 862-947 Sentence denotes A hyperinsulinemic response at 30 min was observed in an oral glucose tolerance test.
TextSentencer_T9 948-1171 Sentence denotes Mutational analysis for the WRN gene revealed a homozygous nucleotide substitution 3190C>T in exon 24, resulting in a protein product with replacement of an arginine residue at position 573 by termination codon (Arg987Ter).
T9 948-1171 Sentence denotes Mutational analysis for the WRN gene revealed a homozygous nucleotide substitution 3190C>T in exon 24, resulting in a protein product with replacement of an arginine residue at position 573 by termination codon (Arg987Ter).
TextSentencer_T10 1172-1265 Sentence denotes The mutated WRN protein was unable to translocate into the nucleus in an in vitro cell assay.
T10 1172-1265 Sentence denotes The mutated WRN protein was unable to translocate into the nucleus in an in vitro cell assay.
TextSentencer_T11 1266-1406 Sentence denotes A WS patient with an Arg987Ter mutation has been previously reported in Switzerland, the present case is the first to be identified in Asia.
T11 1266-1406 Sentence denotes A WS patient with an Arg987Ter mutation has been previously reported in Switzerland, the present case is the first to be identified in Asia.
TextSentencer_T12 1407-1588 Sentence denotes This case demonstrates the early clinical features of WS and suggests that metabolic abnormality, including insulin resistance, is not an essential component of WS at disease onset.
T12 1407-1588 Sentence denotes This case demonstrates the early clinical features of WS and suggests that metabolic abnormality, including insulin resistance, is not an essential component of WS at disease onset.
TextSentencer_T13 1589-1736 Sentence denotes Moreover, a follow-up study of such case would be useful to understand how the various clinical symptoms in WS develop and progress over the years.
T13 1589-1736 Sentence denotes Moreover, a follow-up study of such case would be useful to understand how the various clinical symptoms in WS develop and progress over the years.