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PubMed:22033923 JSONTXT 32 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-146 Sentence denotes Interplay between vascular endothelial growth factor (VEGF) and nuclear factor erythroid 2-related factor-2 (Nrf2): implications for preeclampsia.
T1 0-146 Sentence denotes Interplay between vascular endothelial growth factor (VEGF) and nuclear factor erythroid 2-related factor-2 (Nrf2): implications for preeclampsia.
TextSentencer_T2 147-392 Sentence denotes Several recently published studies have suggested that decreasing VEGF levels result in placental oxidative stress in preeclampsia, although the question as to how decreased VEGF concentrations increase oxidative stress still remains unanswered.
T2 147-392 Sentence denotes Several recently published studies have suggested that decreasing VEGF levels result in placental oxidative stress in preeclampsia, although the question as to how decreased VEGF concentrations increase oxidative stress still remains unanswered.
TextSentencer_T3 393-530 Sentence denotes Here, we show that VEGF activated Nrf2, the main regulating factor of the intracellular redox balance, in the cytotrophic cell line BeWo.
T3 393-530 Sentence denotes Here, we show that VEGF activated Nrf2, the main regulating factor of the intracellular redox balance, in the cytotrophic cell line BeWo.
TextSentencer_T4 531-736 Sentence denotes In turn, this activated the production of antioxidative enzymes thioredoxin, thioredoxin reductase, and heme oxygenase-1, which showed a decrease in their expression in the placentas of preeclamptic women.
T4 531-736 Sentence denotes In turn, this activated the production of antioxidative enzymes thioredoxin, thioredoxin reductase, and heme oxygenase-1, which showed a decrease in their expression in the placentas of preeclamptic women.
TextSentencer_T5 737-810 Sentence denotes Nevertheless, this activation occurred without oxidative stress stimulus.
T5 737-810 Sentence denotes Nevertheless, this activation occurred without oxidative stress stimulus.
TextSentencer_T6 811-922 Sentence denotes As a consequence, the activation of Nrf2 protected BeWo cells against H(2)O(2)/Fe(2+)-induced oxidative damage.
T6 811-922 Sentence denotes As a consequence, the activation of Nrf2 protected BeWo cells against H(2)O(2)/Fe(2+)-induced oxidative damage.
TextSentencer_T7 923-987 Sentence denotes We further show that VEGF up-regulated the expression of itself.
T7 923-987 Sentence denotes We further show that VEGF up-regulated the expression of itself.
TextSentencer_T8 988-1220 Sentence denotes A positive feedback loop was described in which VEGF activated Nrf2 in an ERK1/2-dependent manner; the up-regulation of HO-1 expression by Nrf2 augmented the production of carbon monoxide, which in turn up-regulated VEGF expression.
T8 988-1220 Sentence denotes A positive feedback loop was described in which VEGF activated Nrf2 in an ERK1/2-dependent manner; the up-regulation of HO-1 expression by Nrf2 augmented the production of carbon monoxide, which in turn up-regulated VEGF expression.
TextSentencer_T9 1221-1364 Sentence denotes In conclusion, VEGF induces the Nrf2 pathway to protect against oxidative stress and, via a positive feedback loop, to elevate VEGF expression.
T9 1221-1364 Sentence denotes In conclusion, VEGF induces the Nrf2 pathway to protect against oxidative stress and, via a positive feedback loop, to elevate VEGF expression.
TextSentencer_T10 1365-1595 Sentence denotes Therefore, decreased VEGF bioavailability during preeclampsia may result in higher vulnerability to placental oxidative cell damage and a further reduction of VEGF bioavailability, a vicious circle that may end up in preeclampsia.
T10 1365-1595 Sentence denotes Therefore, decreased VEGF bioavailability during preeclampsia may result in higher vulnerability to placental oxidative cell damage and a further reduction of VEGF bioavailability, a vicious circle that may end up in preeclampsia.