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PubMed:21969818 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-127 Sentence denotes Inhibition of cyclin-dependent kinase phosphorylation of FOXO1 and prostate cancer cell growth by a peptide derived from FOXO1.
T1 0-127 Sentence denotes Inhibition of cyclin-dependent kinase phosphorylation of FOXO1 and prostate cancer cell growth by a peptide derived from FOXO1.
TextSentencer_T2 128-206 Sentence denotes Increasing evidence suggests that FOXO1 possesses a tumor suppressor function.
T2 128-206 Sentence denotes Increasing evidence suggests that FOXO1 possesses a tumor suppressor function.
TextSentencer_T3 207-351 Sentence denotes Inactivation of FOXO1 has been documented in many types of human cancer, and restoring the activity of FOXO1 holds promise for cancer treatment.
T3 207-351 Sentence denotes Inactivation of FOXO1 has been documented in many types of human cancer, and restoring the activity of FOXO1 holds promise for cancer treatment.
TextSentencer_T4 352-558 Sentence denotes In this study, we identified a FOXO1-derived peptide termed FO1-6nls that inhibits cyclin-dependent kinases 1 and 2 (CDK1/2)-mediated phosphorylation of FOXO1 at the serine 249 residue in vitro and in vivo.
T4 352-558 Sentence denotes In this study, we identified a FOXO1-derived peptide termed FO1-6nls that inhibits cyclin-dependent kinases 1 and 2 (CDK1/2)-mediated phosphorylation of FOXO1 at the serine 249 residue in vitro and in vivo.
TextSentencer_T5 559-733 Sentence denotes Overexpression of FO1-6nls in prostate cancer (PCa) cells not only blocked CDK1-induced cytoplasmic localization of FOXO1 but also augmented FOXO1's transcriptional activity.
T5 559-733 Sentence denotes Overexpression of FO1-6nls in prostate cancer (PCa) cells not only blocked CDK1-induced cytoplasmic localization of FOXO1 but also augmented FOXO1's transcriptional activity.
TextSentencer_T6 734-796 Sentence denotes This effect of FO1-6nls requires its binding to CDK1 and CDK2.
T6 734-796 Sentence denotes This effect of FO1-6nls requires its binding to CDK1 and CDK2.
TextSentencer_T7 797-896 Sentence denotes Moreover, the ectopic expression of FO1-6nls inhibited the growth of PTEN-positive DU145 PCa cells.
T7 797-896 Sentence denotes Moreover, the ectopic expression of FO1-6nls inhibited the growth of PTEN-positive DU145 PCa cells.
TextSentencer_T8 897-975 Sentence denotes Importantly, the growth-inhibitory function of FO1-6nls is dependent on FOXO1.
T8 897-975 Sentence denotes Importantly, the growth-inhibitory function of FO1-6nls is dependent on FOXO1.
TextSentencer_T9 976-1094 Sentence denotes Finally, the ectopic expression of FO1-6nls overcame CDK1-mediated inhibition of FOXO1-induced apoptosis of PCa cells.
T9 976-1094 Sentence denotes Finally, the ectopic expression of FO1-6nls overcame CDK1-mediated inhibition of FOXO1-induced apoptosis of PCa cells.
TextSentencer_T10 1095-1353 Sentence denotes These results indicate that the FOXO1-derived peptide FO1-6nls can restore FOXO1's tumor suppressor function by specifically opposing CDK1/2-mediated phosphorylation and inhibition of FOXO1 and hence may have a therapeutic potential for the treatment of PCa.
T10 1095-1353 Sentence denotes These results indicate that the FOXO1-derived peptide FO1-6nls can restore FOXO1's tumor suppressor function by specifically opposing CDK1/2-mediated phosphorylation and inhibition of FOXO1 and hence may have a therapeutic potential for the treatment of PCa.