| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-72 |
Sentence |
denotes |
Silkworm apolipophorin protein inhibits Staphylococcus aureus virulence. |
| T2 |
73-147 |
Sentence |
denotes |
Silkworm hemolymph inhibits hemolysin production by Staphylococcus aureus. |
| T3 |
148-236 |
Sentence |
denotes |
We purified a factor in the silkworm hemolymph responsible for this inhibitory activity. |
| T4 |
237-327 |
Sentence |
denotes |
The final fraction with the greatest specific activity contained 220- and 74-kDa proteins. |
| T5 |
328-533 |
Sentence |
denotes |
Determination of the N-terminal amino acid sequence revealed that the 220- and 74-kDa proteins were apolipophorin I and apolipophorin II, respectively, indicating that the factor was apolipophorin (ApoLp). |
| T6 |
534-729 |
Sentence |
denotes |
The purified ApoLp fraction showed decreased expression of S. aureus hla encoding α-hemolysin, hlb encoding β-hemolysin, saeRS, and RNAIII, which activate the expression of these hemolysin genes. |
| T7 |
730-858 |
Sentence |
denotes |
Injection of an anti-ApoLp antibody into the hemolymph increased the sensitivity of silkworms to the lethal effect of S. aureus. |
| T8 |
859-960 |
Sentence |
denotes |
Hog gastric mucin, a mammalian homologue of ApoLp, decreased the expression of S. aureus hla and hlb. |
| T9 |
961-1159 |
Sentence |
denotes |
These findings suggest that ApoLp in the silkworm hemolymph inhibits S. aureus virulence and contributes to defense against S. aureus infection and that its activity is conserved in mammalian mucin. |
