> top > projects > sentences > docs > PubMed:21871071 > annotations
sentences Home  

PubMed:21871071 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-109 Sentence denotes EFS shows biallelic methylation in uveal melanoma with poor prognosis as well as tissue-specific methylation.
T1 0-109 Sentence denotes EFS shows biallelic methylation in uveal melanoma with poor prognosis as well as tissue-specific methylation.
TextSentencer_T2 110-121 Sentence denotes BACKGROUND:
T2 110-121 Sentence denotes BACKGROUND:
TextSentencer_T3 122-162 Sentence denotes Uveal melanoma (UM) is a rare eye tumor.
T3 122-162 Sentence denotes Uveal melanoma (UM) is a rare eye tumor.
TextSentencer_T4 163-280 Sentence denotes There are two classes of UM, which can be discriminated by the chromosome 3 status or global mRNA expression profile.
T4 163-280 Sentence denotes There are two classes of UM, which can be discriminated by the chromosome 3 status or global mRNA expression profile.
TextSentencer_T5 281-420 Sentence denotes Metastatic progression is predominantly originated from class II tumors or from tumors showing loss of an entire chromosome 3 (monosomy 3).
T5 281-420 Sentence denotes Metastatic progression is predominantly originated from class II tumors or from tumors showing loss of an entire chromosome 3 (monosomy 3).
TextSentencer_T6 421-694 Sentence denotes We performed detailed EFS (embryonal Fyn-associated substrate) methylation analyses in UM, cultured uveal melanocytes and normal tissues, to explore the role of the differentially methylated EFS promoter region CpG island in tumor classification and metastatic progression.
T6 421-694 Sentence denotes We performed detailed EFS (embryonal Fyn-associated substrate) methylation analyses in UM, cultured uveal melanocytes and normal tissues, to explore the role of the differentially methylated EFS promoter region CpG island in tumor classification and metastatic progression.
TextSentencer_T7 695-857 Sentence denotes METHODS: EFS methylation was determined by direct sequencing of PCR products from bisulfite-treated DNA or by sequence analysis of individual cloned PCR products.
T7 695-857 Sentence denotes METHODS: EFS methylation was determined by direct sequencing of PCR products from bisulfite-treated DNA or by sequence analysis of individual cloned PCR products.
TextSentencer_T8 858-955 Sentence denotes The results were associated with clinical features of tumors and tumor-related death of patients.
T8 858-955 Sentence denotes The results were associated with clinical features of tumors and tumor-related death of patients.
TextSentencer_T9 956-964 Sentence denotes RESULTS:
T9 956-964 Sentence denotes RESULTS:
TextSentencer_T10 965-1109 Sentence denotes Analysis of 16 UM showed full methylation of the EFS CpG island in 8 (50%), no methylation in 5 (31%) and partial methylation in 3 (19%) tumors.
T10 965-1109 Sentence denotes Analysis of 16 UM showed full methylation of the EFS CpG island in 8 (50%), no methylation in 5 (31%) and partial methylation in 3 (19%) tumors.
TextSentencer_T11 1110-1224 Sentence denotes Kaplan-Meier analysis revealed a higher risk of metastatic progression for tumors with EFS methylation (p = 0.02).
T11 1110-1224 Sentence denotes Kaplan-Meier analysis revealed a higher risk of metastatic progression for tumors with EFS methylation (p = 0.02).
TextSentencer_T12 1225-1307 Sentence denotes This correlation was confirmed in an independent set of 24 randomly chosen tumors.
T12 1225-1307 Sentence denotes This correlation was confirmed in an independent set of 24 randomly chosen tumors.
TextSentencer_T13 1308-1370 Sentence denotes Notably, only UM with EFS methylation gave rise to metastases.
T13 1308-1370 Sentence denotes Notably, only UM with EFS methylation gave rise to metastases.
TextSentencer_T14 1371-1514 Sentence denotes Real-time quantitative RT-PCR expression analysis revealed a significant inverse correlation of EFS mRNA expression with EFS methylation in UM.
T14 1371-1514 Sentence denotes Real-time quantitative RT-PCR expression analysis revealed a significant inverse correlation of EFS mRNA expression with EFS methylation in UM.
TextSentencer_T15 1515-1714 Sentence denotes We further found that EFS methylation is tissue-specific with full methylation in peripheral blood cells, and no methylation in sperm, cultured primary fibroblasts and fetal muscle, kidney and brain.
T15 1515-1714 Sentence denotes We further found that EFS methylation is tissue-specific with full methylation in peripheral blood cells, and no methylation in sperm, cultured primary fibroblasts and fetal muscle, kidney and brain.
TextSentencer_T16 1715-1849 Sentence denotes Adult brain samples, cultured melanocytes from the uveal tract, fetal liver and 3 of 4 buccal swab samples showed partial methylation.
T16 1715-1849 Sentence denotes Adult brain samples, cultured melanocytes from the uveal tract, fetal liver and 3 of 4 buccal swab samples showed partial methylation.
TextSentencer_T17 1850-1922 Sentence denotes EFS methylation always affects both alleles in normal and tumor samples.
T17 1850-1922 Sentence denotes EFS methylation always affects both alleles in normal and tumor samples.
TextSentencer_T18 1923-1935 Sentence denotes CONCLUSIONS:
T18 1923-1935 Sentence denotes CONCLUSIONS:
TextSentencer_T19 1936-2030 Sentence denotes Biallelic EFS methylation is likely to be the result of a site-directed methylation mechanism.
T19 1936-2030 Sentence denotes Biallelic EFS methylation is likely to be the result of a site-directed methylation mechanism.
TextSentencer_T20 2031-2202 Sentence denotes Based on partial methylation as observed in cultured melanocytes we hypothesize that there might be methylated and unmethylated precursor cells located in the uveal tract.
T20 2031-2202 Sentence denotes Based on partial methylation as observed in cultured melanocytes we hypothesize that there might be methylated and unmethylated precursor cells located in the uveal tract.
TextSentencer_T21 2203-2300 Sentence denotes The EFS methylation of a UM may depend on which type of precursor cell the tumor originated from.
T21 2203-2300 Sentence denotes The EFS methylation of a UM may depend on which type of precursor cell the tumor originated from.