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PubMed:21632547 JSONTXT 25 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-91 Sentence denotes The conserved Rieske oxygenase DAF-36/Neverland is a novel cholesterol-metabolizing enzyme.
T2 92-199 Sentence denotes Steroid hormones play essential roles in a wide variety of biological processes in multicellular organisms.
T3 200-390 Sentence denotes The principal steroid hormones in nematodes and arthropods are dafachronic acids and ecdysteroids, respectively, both of which are synthesized from cholesterol as an indispensable precursor.
T4 391-531 Sentence denotes The first critical catalytic step in the biosynthesis of these ecdysozoan steroids is the conversion of cholesterol to 7-dehydrocholesterol.
T5 532-639 Sentence denotes However, the enzymes responsible for cholesterol 7,8-dehydrogenation remain unclear at the molecular level.
T6 640-739 Sentence denotes Here we report that the Rieske oxygenase DAF-36/Neverland (Nvd) is a cholesterol 7,8-dehydrogenase.
T7 740-1051 Sentence denotes The daf-36/nvd genes are evolutionarily conserved, not only in nematodes and insects but also in deuterostome species that do not produce dafachronic acids or ecdysteroids, including the sea urchin Hemicentrotus pulcherrimus, the sea squirt Ciona intestinalis, the fish Danio rerio, and the frog Xenopus laevis.
T8 1052-1202 Sentence denotes An in vitro enzymatic assay system reveals that all DAF-36/Nvd proteins cloned so far have the ability to convert cholesterol to 7-dehydrocholesterol.
T9 1203-1449 Sentence denotes Moreover, the lethality of loss of nvd function in the fruit fly Drosophila melanogaster is rescued by the expression of daf-36/nvd genes from the nematode Caenorhabditis elegans, the insect Bombyx mori, or the vertebrates D. rerio and X. laevis.
T10 1450-1552 Sentence denotes These data suggest that daf-36/nvd genes are functionally orthologous across the bilaterian phylogeny.
T11 1553-1681 Sentence denotes We propose that the daf-36/nvd family of proteins is a novel conserved player in cholesterol metabolism across the animal phyla.