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PubMed:21523445 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-122 Sentence denotes Klotho, an anti-senescence related gene, is frequently inactivated through promoter hypermethylation in colorectal cancer.
T1 0-122 Sentence denotes Klotho, an anti-senescence related gene, is frequently inactivated through promoter hypermethylation in colorectal cancer.
TextSentencer_T2 123-307 Sentence denotes The potential anti-senescence gene Klotho (KL) has been recently found to participate in the progression of several different human cancers including breast, lung, and cervical cancer.
T2 123-307 Sentence denotes The potential anti-senescence gene Klotho (KL) has been recently found to participate in the progression of several different human cancers including breast, lung, and cervical cancer.
TextSentencer_T3 308-455 Sentence denotes In this current study, we identified KL as a candidate tumor suppressor gene silenced through promoter hypermethylation in colorectal cancer (CRC).
T3 308-455 Sentence denotes In this current study, we identified KL as a candidate tumor suppressor gene silenced through promoter hypermethylation in colorectal cancer (CRC).
TextSentencer_T4 456-677 Sentence denotes KL gene expression is found to be absent or reduced in colon cancer cell lines (5/6, 83.3%), which can be reversed by treatment with demethylation agent 5-aza-2'-deoxycytidine (Aza), but not HDAC inhibitor trichostatin A.
T4 456-677 Sentence denotes KL gene expression is found to be absent or reduced in colon cancer cell lines (5/6, 83.3%), which can be reversed by treatment with demethylation agent 5-aza-2'-deoxycytidine (Aza), but not HDAC inhibitor trichostatin A.
TextSentencer_T5 678-826 Sentence denotes In addition, KL expression is markedly downregulated in colorectal carcinoma tissues when compared to the adjacent nontumor tissues (n=25, p<0.001).
T5 678-826 Sentence denotes In addition, KL expression is markedly downregulated in colorectal carcinoma tissues when compared to the adjacent nontumor tissues (n=25, p<0.001).
TextSentencer_T6 827-980 Sentence denotes The methylation of the KL gene promoter was frequently detected in primary tumor tissues (34/40, 85%) when compared with adjacent nontumor colon tissues.
T6 827-980 Sentence denotes The methylation of the KL gene promoter was frequently detected in primary tumor tissues (34/40, 85%) when compared with adjacent nontumor colon tissues.
TextSentencer_T7 981-1153 Sentence denotes Furthermore, ectopic expression of KL led to the cell proliferation inhibition of colon cancer cell lines via the induction of cell apoptosis and S-phase cell cycle arrest.
T7 981-1153 Sentence denotes Furthermore, ectopic expression of KL led to the cell proliferation inhibition of colon cancer cell lines via the induction of cell apoptosis and S-phase cell cycle arrest.
TextSentencer_T8 1154-1307 Sentence denotes Taken together, our results suggest that KL is inactivated through promoter hypermethylation and potentially functions as a tumor suppressor gene in CRC.
T8 1154-1307 Sentence denotes Taken together, our results suggest that KL is inactivated through promoter hypermethylation and potentially functions as a tumor suppressor gene in CRC.