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PubMed:21421994 JSONTXT 49 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-103 Sentence denotes High-mannose glycans on the Fc region of therapeutic IgG antibodies increase serum clearance in humans.
T1 0-103 Sentence denotes High-mannose glycans on the Fc region of therapeutic IgG antibodies increase serum clearance in humans.
T1 0-103 Sentence denotes High-mannose glycans on the Fc region of therapeutic IgG antibodies increase serum clearance in humans.
TextSentencer_T2 104-293 Sentence denotes Glycan structures attached to the C(H)2 domain of the Fc region of immunoglobulin G (IgG) are essential for specific effector functions but their role in modulating clearance is less clear.
T2 104-293 Sentence denotes Glycan structures attached to the C(H)2 domain of the Fc region of immunoglobulin G (IgG) are essential for specific effector functions but their role in modulating clearance is less clear.
T2 104-293 Sentence denotes Glycan structures attached to the C(H)2 domain of the Fc region of immunoglobulin G (IgG) are essential for specific effector functions but their role in modulating clearance is less clear.
TextSentencer_T3 294-406 Sentence denotes Clearance is of obvious importance for therapeutic monoclonal antibodies (Mabs) as it directly impacts efficacy.
T3 294-406 Sentence denotes Clearance is of obvious importance for therapeutic monoclonal antibodies (Mabs) as it directly impacts efficacy.
T3 294-406 Sentence denotes Clearance is of obvious importance for therapeutic monoclonal antibodies (Mabs) as it directly impacts efficacy.
TextSentencer_T4 407-541 Sentence denotes Here, we study the impact of Fc glycan structure on the clearance of four therapeutic human IgGs (one IgG1 and three IgG2s) in humans.
T4 407-541 Sentence denotes Here, we study the impact of Fc glycan structure on the clearance of four therapeutic human IgGs (one IgG1 and three IgG2s) in humans.
T4 407-541 Sentence denotes Here, we study the impact of Fc glycan structure on the clearance of four therapeutic human IgGs (one IgG1 and three IgG2s) in humans.
TextSentencer_T5 542-764 Sentence denotes The therapeutic IgGs were affinity purified from serum samples from human pharmacokinetic studies, and changes to the glycan profile over time were determined by peptide mapping employing high-resolution mass spectrometry.
T5 542-764 Sentence denotes The therapeutic IgGs were affinity purified from serum samples from human pharmacokinetic studies, and changes to the glycan profile over time were determined by peptide mapping employing high-resolution mass spectrometry.
T5 542-764 Sentence denotes The therapeutic IgGs were affinity purified from serum samples from human pharmacokinetic studies, and changes to the glycan profile over time were determined by peptide mapping employing high-resolution mass spectrometry.
TextSentencer_T6 765-896 Sentence denotes Relative levels of high-mannose 5 (M5) glycan decreased as a function of circulation time, whereas other glycans remained constant.
T6 765-896 Sentence denotes Relative levels of high-mannose 5 (M5) glycan decreased as a function of circulation time, whereas other glycans remained constant.
T6 765-896 Sentence denotes Relative levels of high-mannose 5 (M5) glycan decreased as a function of circulation time, whereas other glycans remained constant.
TextSentencer_T7 897-1039 Sentence denotes These results demonstrate that therapeutic IgGs containing Fc high-mannose glycans are cleared more rapidly in humans than other glycan forms.
T7 897-1039 Sentence denotes These results demonstrate that therapeutic IgGs containing Fc high-mannose glycans are cleared more rapidly in humans than other glycan forms.
T7 897-1039 Sentence denotes These results demonstrate that therapeutic IgGs containing Fc high-mannose glycans are cleared more rapidly in humans than other glycan forms.
TextSentencer_T8 1040-1327 Sentence denotes The quantitative effect of this on pharmacokinetic area under the curve was calculated and shown to be relatively minor for three of the four molecules studied, but, depending on the dosing regimen and the relative level of the high-mannose glycan, this can also have significant impact.
T8 1040-1327 Sentence denotes The quantitative effect of this on pharmacokinetic area under the curve was calculated and shown to be relatively minor for three of the four molecules studied, but, depending on the dosing regimen and the relative level of the high-mannose glycan, this can also have significant impact.
T8 1040-1327 Sentence denotes The quantitative effect of this on pharmacokinetic area under the curve was calculated and shown to be relatively minor for three of the four molecules studied, but, depending on the dosing regimen and the relative level of the high-mannose glycan, this can also have significant impact.
TextSentencer_T9 1328-1499 Sentence denotes High-mannose content of therapeutic Mabs should be considered an important product quality attribute which may affect pharmacokinetic properties of therapeutic antibodies.
T9 1328-1499 Sentence denotes High-mannose content of therapeutic Mabs should be considered an important product quality attribute which may affect pharmacokinetic properties of therapeutic antibodies.
T9 1328-1499 Sentence denotes High-mannose content of therapeutic Mabs should be considered an important product quality attribute which may affect pharmacokinetic properties of therapeutic antibodies.