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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-129 Sentence denotes Protocadherin-12 cleavage is a regulated process mediated by ADAM10 protein: evidence of shedding up-regulation in pre-eclampsia.
T1 0-129 Sentence denotes Protocadherin-12 cleavage is a regulated process mediated by ADAM10 protein: evidence of shedding up-regulation in pre-eclampsia.
TextSentencer_T2 130-253 Sentence denotes Protocadherins are a group of transmembrane proteins with homophilic binding activity, members of the cadherin superfamily.
T2 130-253 Sentence denotes Protocadherins are a group of transmembrane proteins with homophilic binding activity, members of the cadherin superfamily.
TextSentencer_T3 254-354 Sentence denotes Apart from their role in adhesion, the cellular functions of protocadherins are essentially unknown.
T3 254-354 Sentence denotes Apart from their role in adhesion, the cellular functions of protocadherins are essentially unknown.
TextSentencer_T4 355-478 Sentence denotes Protocadherin (PCDH)12 was previously identified in invasive trophoblasts and endothelial and mesangial cells in the mouse.
T4 355-478 Sentence denotes Protocadherin (PCDH)12 was previously identified in invasive trophoblasts and endothelial and mesangial cells in the mouse.
TextSentencer_T5 479-573 Sentence denotes Invalidation studies revealed that the protein was required for optimal placental development.
T5 479-573 Sentence denotes Invalidation studies revealed that the protein was required for optimal placental development.
TextSentencer_T6 574-741 Sentence denotes In this article, we show that its human homolog is abundantly expressed in various trophoblast subtypes of the human placenta and at lower levels in endothelial cells.
T6 574-741 Sentence denotes In this article, we show that its human homolog is abundantly expressed in various trophoblast subtypes of the human placenta and at lower levels in endothelial cells.
TextSentencer_T7 742-800 Sentence denotes We demonstrate that PCDH12 is shed at high rates in vitro.
T7 742-800 Sentence denotes We demonstrate that PCDH12 is shed at high rates in vitro.
TextSentencer_T8 801-909 Sentence denotes The shedding mechanism depends on ADAM10 and results in reduced cellular adhesion in a cell migration assay.
T8 801-909 Sentence denotes The shedding mechanism depends on ADAM10 and results in reduced cellular adhesion in a cell migration assay.
TextSentencer_T9 910-1034 Sentence denotes PCDH12 is subsequently cleaved by the γ-secretase complex, and its cytoplasmic domain is rapidly degraded by the proteasome.
T9 910-1034 Sentence denotes PCDH12 is subsequently cleaved by the γ-secretase complex, and its cytoplasmic domain is rapidly degraded by the proteasome.
TextSentencer_T10 1035-1204 Sentence denotes PCDH12 shedding is regulated by interlinked intracellular pathways, including those involving protein kinase C, PI3K, and cAMP, that either increase or inhibit cleavage.
T10 1035-1204 Sentence denotes PCDH12 shedding is regulated by interlinked intracellular pathways, including those involving protein kinase C, PI3K, and cAMP, that either increase or inhibit cleavage.
TextSentencer_T11 1205-1292 Sentence denotes In endothelial cells, VEGF, prostaglandin E(2), or histamine regulates PCDH12 shedding.
T11 1205-1292 Sentence denotes In endothelial cells, VEGF, prostaglandin E(2), or histamine regulates PCDH12 shedding.
TextSentencer_T12 1293-1423 Sentence denotes The extracellular domain of PCDH12 was also detected in human serum and urine, thus providing evidence of PCDH12 shedding in vivo.
T12 1293-1423 Sentence denotes The extracellular domain of PCDH12 was also detected in human serum and urine, thus providing evidence of PCDH12 shedding in vivo.
TextSentencer_T13 1424-1632 Sentence denotes Importantly, we observed an increase in circulating PCDH12 in pregnant women who later developed a pre-eclampsia, a frequent pregnancy syndrome and a major cause of maternal and fetal morbidity and mortality.
T13 1424-1632 Sentence denotes Importantly, we observed an increase in circulating PCDH12 in pregnant women who later developed a pre-eclampsia, a frequent pregnancy syndrome and a major cause of maternal and fetal morbidity and mortality.
TextSentencer_T14 1633-1877 Sentence denotes In conclusion, we speculate that, like in mice, PCDH12 may play an important role in human placental development and that proteolytic cleavage in response to external factors, such as cytokines and pathological settings, regulates its activity.
T14 1633-1877 Sentence denotes In conclusion, we speculate that, like in mice, PCDH12 may play an important role in human placental development and that proteolytic cleavage in response to external factors, such as cytokines and pathological settings, regulates its activity.