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PubMed:21388952 JSONTXT 40 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-164 Sentence denotes Loss of p53 and acquisition of angiogenic microRNA profile are insufficient to facilitate progression of bladder urothelial carcinoma in situ to invasive carcinoma.
T2 165-300 Sentence denotes Activation of oncogenes or inactivation of tumor suppressors in urothelium is considered critical for development of urothelial cancer.
T3 301-489 Sentence denotes Here we report cloning of the urothelium-specific promoter uroplakin-II (UPK II) and generation of transgenic mice in which expression of SV40 large T antigen is driven by UPK II promoter.
T4 490-647 Sentence denotes Inactivation of tumor suppressor p53 and pRb in urothelium by SV40 T antigen resulted in urothelial carcinoma, resembling human high-grade carcinoma in situ.
T5 648-793 Sentence denotes Specific deletion of p53 in urothelial cells using the newly generated UPK II-Cre mice results in normal bladders without any evidence of cancer.
T6 794-1017 Sentence denotes The high-grade carcinoma in situ in the UPK II-SV40 mice is associated with significant activation of angiogenic signals consisting of hypoxia-inducible factor-1α (HIF-1α) and VEGF and a down-regulation of thrombospondin-1.
T7 1018-1117 Sentence denotes Interestingly, such pro-angiogenic activity was not associated with progression to invasive cancer.
T8 1118-1305 Sentence denotes Analysis of bladder-associated microRNAs in carcinoma in situ lesions reveals a pro-angiogenic profile, with specific overexpression of miR-18a and miR-19a and down-regulation of miR-107.
T9 1306-1436 Sentence denotes A group of microRNAs (miRs) identified as associated with invasive human urothelial cancer remained unchanged in this mouse model.
T10 1437-1584 Sentence denotes Collectively, our results support the notion that activation of angiogenesis and loss of p53 are not sufficient for progression to invasive cancer.
T11 1585-1747 Sentence denotes Our studies identify a new mouse model for bladder cancer that can be used to study factors that determine progression to an invasive phenotype of bladder cancer.