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PubMed:21364582 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-115 Sentence denotes DSC3 expression is regulated by p53, and methylation of DSC3 DNA is a prognostic marker in human colorectal cancer.
T1 0-115 Sentence denotes DSC3 expression is regulated by p53, and methylation of DSC3 DNA is a prognostic marker in human colorectal cancer.
TextSentencer_T2 116-127 Sentence denotes BACKGROUND:
T2 116-127 Sentence denotes BACKGROUND:
TextSentencer_T3 128-255 Sentence denotes Desmocollin 3 (DSC3), a member of the cadherin superfamily and integral component of desmosomes, is involved in carcinogenesis.
T3 128-255 Sentence denotes Desmocollin 3 (DSC3), a member of the cadherin superfamily and integral component of desmosomes, is involved in carcinogenesis.
TextSentencer_T4 256-338 Sentence denotes However, the role of DSC3 in colorectal cancer (CRC) has not yet been established.
T4 256-338 Sentence denotes However, the role of DSC3 in colorectal cancer (CRC) has not yet been established.
TextSentencer_T5 339-347 Sentence denotes METHODS:
T5 339-347 Sentence denotes METHODS:
TextSentencer_T6 348-435 Sentence denotes Desmocollin 3 expression in CRC cell lines was analysed by RT-PCR and western blotting.
T6 348-435 Sentence denotes Desmocollin 3 expression in CRC cell lines was analysed by RT-PCR and western blotting.
TextSentencer_T7 436-557 Sentence denotes Methylation status of DSC3 was examined by demethylation tests, methylation-specific PCR, and bisulphite sequencing (BS).
T7 436-557 Sentence denotes Methylation status of DSC3 was examined by demethylation tests, methylation-specific PCR, and bisulphite sequencing (BS).
TextSentencer_T8 558-618 Sentence denotes The regulatory role of p53 was investigated by transfection.
T8 558-618 Sentence denotes The regulatory role of p53 was investigated by transfection.
TextSentencer_T9 619-627 Sentence denotes RESULTS:
T9 619-627 Sentence denotes RESULTS:
TextSentencer_T10 628-700 Sentence denotes Desmocollin 3 was downregulated in CRC cells at mRNA and protein levels.
T10 628-700 Sentence denotes Desmocollin 3 was downregulated in CRC cells at mRNA and protein levels.
TextSentencer_T11 701-816 Sentence denotes Desmocollin 3 expression was restored in five out of seven cell lines after 5-aza-2'-deoxycytidine (DAC) treatment.
T11 701-816 Sentence denotes Desmocollin 3 expression was restored in five out of seven cell lines after 5-aza-2'-deoxycytidine (DAC) treatment.
TextSentencer_T12 817-910 Sentence denotes A heterogeneous methylation pattern was detected by BS in promoter region and exon 1 of DSC3.
T12 817-910 Sentence denotes A heterogeneous methylation pattern was detected by BS in promoter region and exon 1 of DSC3.
TextSentencer_T13 911-1044 Sentence denotes Methylation of DSC3 genomic sequences was found in 41% (41 out of 99) of primary CRC, being associated with poor prognosis (P=0.002).
T13 911-1044 Sentence denotes Methylation of DSC3 genomic sequences was found in 41% (41 out of 99) of primary CRC, being associated with poor prognosis (P=0.002).
TextSentencer_T14 1045-1126 Sentence denotes Transfection of p53 alone or in combination of DAC increased the DSC3 expression.
T14 1045-1126 Sentence denotes Transfection of p53 alone or in combination of DAC increased the DSC3 expression.
TextSentencer_T15 1127-1234 Sentence denotes Similarly, treatment with p53 inducer adriamycin alone or in combination with DAC enhanced DSC3 expression.
T15 1127-1234 Sentence denotes Similarly, treatment with p53 inducer adriamycin alone or in combination with DAC enhanced DSC3 expression.
TextSentencer_T16 1235-1320 Sentence denotes CONCLUSIONS: DNA methylation contributes to downregulation of DSC3 in CRC cell lines.
T16 1235-1320 Sentence denotes CONCLUSIONS: DNA methylation contributes to downregulation of DSC3 in CRC cell lines.
TextSentencer_T17 1321-1383 Sentence denotes Methylation status of DSC3 DNA is a prognostic marker for CRC.
T17 1321-1383 Sentence denotes Methylation status of DSC3 DNA is a prognostic marker for CRC.
TextSentencer_T18 1384-1452 Sentence denotes P53 appears to have an important role in regulating DSC3 expression.
T18 1384-1452 Sentence denotes P53 appears to have an important role in regulating DSC3 expression.