| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-93 |
Sentence |
denotes |
Involvement of DNA-dependent protein kinase in normal cell cycle progression through mitosis. |
| T2 |
94-293 |
Sentence |
denotes |
The catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) plays an important role in DNA double-strand break (DSB) repair as the underlying mechanism of the non-homologous end joining pathway. |
| T3 |
294-444 |
Sentence |
denotes |
When DSBs occur, DNA-PKcs is rapidly phosphorylated at both the Thr-2609 and Ser-2056 residues, and such phosphorylations are critical for DSB repair. |
| T4 |
445-600 |
Sentence |
denotes |
In this study we report that, in addition to responding to DSBs, DNA-PKcs is activated and phosphorylated in normal cell cycle progression through mitosis. |
| T5 |
601-728 |
Sentence |
denotes |
Mitotic induction of DNA-PKcs phosphorylation is closely associated with the spindle apparatus at centrosomes and kinetochores. |
| T6 |
729-899 |
Sentence |
denotes |
Furthermore, depletion of DNA-PKcs protein levels or inhibition of DNA-PKcs kinase activity results in the delay of mitotic transition because of chromosome misalignment. |
| T7 |
900-1100 |
Sentence |
denotes |
These results demonstrate for the first time that DNA-PKcs, in addition to its role in DSB repair, is a critical regulator of mitosis and could modulate microtubule dynamics in chromosome segregation. |
