| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-118 |
Sentence |
denotes |
A novel apolipoprotein E mutation, ApoE Osaka (Arg158 Pro), in a dyslipidemic patient with lipoprotein glomerulopathy. |
| T1 |
0-118 |
Sentence |
denotes |
A novel apolipoprotein E mutation, ApoE Osaka (Arg158 Pro), in a dyslipidemic patient with lipoprotein glomerulopathy. |
| TextSentencer_T2 |
119-347 |
Sentence |
denotes |
Lipoprotein glomerulopathy (LPG) is a rare disease characterized by the presence of thrombuslike deposition in markedly dilated glomerular capillaries and is often accompanied by an increased serum apolipoprotein E (apoE) level. |
| T2 |
119-347 |
Sentence |
denotes |
Lipoprotein glomerulopathy (LPG) is a rare disease characterized by the presence of thrombuslike deposition in markedly dilated glomerular capillaries and is often accompanied by an increased serum apolipoprotein E (apoE) level. |
| TextSentencer_T3 |
348-424 |
Sentence |
denotes |
Several gene mutations of apoE have been reported to be associated with LPG. |
| T3 |
348-424 |
Sentence |
denotes |
Several gene mutations of apoE have been reported to be associated with LPG. |
| TextSentencer_T4 |
425-511 |
Sentence |
denotes |
In the current study, we report an LPG patient with a novel apoE mutation, apoE Osaka. |
| T4 |
425-511 |
Sentence |
denotes |
In the current study, we report an LPG patient with a novel apoE mutation, apoE Osaka. |
| TextSentencer_T5 |
512-593 |
Sentence |
denotes |
The patient was a 45-year-old man who was hospitalized due to nephrotic syndrome. |
| T5 |
512-593 |
Sentence |
denotes |
The patient was a 45-year-old man who was hospitalized due to nephrotic syndrome. |
| TextSentencer_T6 |
594-776 |
Sentence |
denotes |
Light and electron microscopic observations of renal biopsy clearly showed characteristic findings of LPG, including lamellate thrombi in the lumen of dilated glomerular capillaries. |
| T6 |
594-776 |
Sentence |
denotes |
Light and electron microscopic observations of renal biopsy clearly showed characteristic findings of LPG, including lamellate thrombi in the lumen of dilated glomerular capillaries. |
| TextSentencer_T7 |
777-891 |
Sentence |
denotes |
His apoE phenotype was apoE3/2 and he had mild dyslipidemia with a mid-band on polyacrylamide gel electrophoresis. |
| T7 |
777-891 |
Sentence |
denotes |
His apoE phenotype was apoE3/2 and he had mild dyslipidemia with a mid-band on polyacrylamide gel electrophoresis. |
| TextSentencer_T8 |
892-960 |
Sentence |
denotes |
It is intriguing that the serum apoE level was within normal limits. |
| T8 |
892-960 |
Sentence |
denotes |
It is intriguing that the serum apoE level was within normal limits. |
| TextSentencer_T9 |
961-1077 |
Sentence |
denotes |
We determined the sequence of the apoE gene using direct sequencing of the polymerase chain reaction (PCR) products. |
| T9 |
961-1077 |
Sentence |
denotes |
We determined the sequence of the apoE gene using direct sequencing of the polymerase chain reaction (PCR) products. |
| TextSentencer_T10 |
1078-1163 |
Sentence |
denotes |
ApoE gene analysis showed a nucleotide substitution of G to C at codon 158 of exon 4. |
| T10 |
1078-1163 |
Sentence |
denotes |
ApoE gene analysis showed a nucleotide substitution of G to C at codon 158 of exon 4. |
| TextSentencer_T11 |
1164-1281 |
Sentence |
denotes |
This mutation denoted an amino acid substitution of arginine residue for the proline residue at position 158 of apoE. |
| T11 |
1164-1281 |
Sentence |
denotes |
This mutation denoted an amino acid substitution of arginine residue for the proline residue at position 158 of apoE. |
| TextSentencer_T12 |
1282-1416 |
Sentence |
denotes |
The result of PCR associated with restriction fragment length polymorphism analysis also suggested that this mutation is heterozygous. |
| T12 |
1282-1416 |
Sentence |
denotes |
The result of PCR associated with restriction fragment length polymorphism analysis also suggested that this mutation is heterozygous. |
| TextSentencer_T13 |
1417-1630 |
Sentence |
denotes |
It is possible that apoE Osaka mutation causes a conformational change of apoE protein and affects the interaction between abnormal apoE-containing lipoproteins and the endothelial cells of glomerular capillaries. |
| T13 |
1417-1630 |
Sentence |
denotes |
It is possible that apoE Osaka mutation causes a conformational change of apoE protein and affects the interaction between abnormal apoE-containing lipoproteins and the endothelial cells of glomerular capillaries. |
| TextSentencer_T14 |
1631-1719 |
Sentence |
denotes |
The precise mechanism of LPG related with apoE Osaka, however, remains to be elucidated. |
| T14 |
1631-1719 |
Sentence |
denotes |
The precise mechanism of LPG related with apoE Osaka, however, remains to be elucidated. |