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PubMed:21281310 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-176 Sentence denotes CCAAT/enhancer binding protein β expression is increased in the brain during HIV-1-infection and contributes to regulation of astrocyte tissue inhibitor of metalloproteinase-1.
T1 0-176 Sentence denotes CCAAT/enhancer binding protein β expression is increased in the brain during HIV-1-infection and contributes to regulation of astrocyte tissue inhibitor of metalloproteinase-1.
TextSentencer_T2 177-365 Sentence denotes Human immunodeficiency virus (HIV)-1-associated neurocognitive disorders (HAND) associated with infection and activation of mononuclear phagocytes (MP) in the brain, occur late in disease.
T2 177-365 Sentence denotes Human immunodeficiency virus (HIV)-1-associated neurocognitive disorders (HAND) associated with infection and activation of mononuclear phagocytes (MP) in the brain, occur late in disease.
TextSentencer_T3 366-482 Sentence denotes Infected/activated MP initiate neuroinflammation activating glial cells and ultimately disrupting neuronal function.
T3 366-482 Sentence denotes Infected/activated MP initiate neuroinflammation activating glial cells and ultimately disrupting neuronal function.
TextSentencer_T4 483-578 Sentence denotes Astrocytes secrete tissue inhibitor of metalloproteinase (TIMP)-1 in response to neural injury.
T4 483-578 Sentence denotes Astrocytes secrete tissue inhibitor of metalloproteinase (TIMP)-1 in response to neural injury.
TextSentencer_T5 579-640 Sentence denotes Altered TIMP-1 levels are implicated in several CNS diseases.
T5 579-640 Sentence denotes Altered TIMP-1 levels are implicated in several CNS diseases.
TextSentencer_T6 641-825 Sentence denotes CCAAT enhancer-binding protein β (C/EBPβ), a transcription factor, is expressed in rodent brains in response to neuroinflammation, implicating it in Alzheimer's, Parkinson's, and HAND.
T6 641-825 Sentence denotes CCAAT enhancer-binding protein β (C/EBPβ), a transcription factor, is expressed in rodent brains in response to neuroinflammation, implicating it in Alzheimer's, Parkinson's, and HAND.
TextSentencer_T7 826-1001 Sentence denotes Here, we report that C/EBPβ mRNA levels are elevated and its isoforms differentially expressed in total brain tissue lysates of HIV-1-infected and HIV-1 encephalitis patients.
T7 826-1001 Sentence denotes Here, we report that C/EBPβ mRNA levels are elevated and its isoforms differentially expressed in total brain tissue lysates of HIV-1-infected and HIV-1 encephalitis patients.
TextSentencer_T8 1002-1126 Sentence denotes In vitro, HAND-relevant stimuli additively induce C/EBPβ nuclear expression in human astrocytes through 7 days of treatment.
T8 1002-1126 Sentence denotes In vitro, HAND-relevant stimuli additively induce C/EBPβ nuclear expression in human astrocytes through 7 days of treatment.
TextSentencer_T9 1127-1264 Sentence denotes Over-expression of C/EBPβ increases TIMP-1 promoter activity, mRNA, and protein levels in human astrocytes activated with interleukin-1β.
T9 1127-1264 Sentence denotes Over-expression of C/EBPβ increases TIMP-1 promoter activity, mRNA, and protein levels in human astrocytes activated with interleukin-1β.
TextSentencer_T10 1265-1337 Sentence denotes Knockdown of C/EBPβ with siRNA decreases TIMP-1 mRNA and protein levels.
T10 1265-1337 Sentence denotes Knockdown of C/EBPβ with siRNA decreases TIMP-1 mRNA and protein levels.
TextSentencer_T11 1338-1569 Sentence denotes These data suggest that C/EBPβ isoforms are involved in complex regulation of astrocyte TIMP-1 production during HIV-1 infection; however, further studies are required to completely understand their role during disease progression.
T11 1338-1569 Sentence denotes These data suggest that C/EBPβ isoforms are involved in complex regulation of astrocyte TIMP-1 production during HIV-1 infection; however, further studies are required to completely understand their role during disease progression.