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PubMed:21209915 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-124 Sentence denotes Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization.
T1 0-124 Sentence denotes Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization.
TextSentencer_T2 125-136 Sentence denotes BACKGROUND:
T2 125-136 Sentence denotes BACKGROUND:
TextSentencer_T3 137-299 Sentence denotes Germline mutations in a tumor suppressor gene FLCN lead to development of fibrofolliculomas, lung cysts and renal cell carcinoma (RCC) in Birt-Hogg-Dubé syndrome.
T3 137-299 Sentence denotes Germline mutations in a tumor suppressor gene FLCN lead to development of fibrofolliculomas, lung cysts and renal cell carcinoma (RCC) in Birt-Hogg-Dubé syndrome.
TextSentencer_T4 300-548 Sentence denotes TFE3 is a member of the MiTF/TFE transcription factor family and Xp11.2 translocations found in sporadic RCC involving TFE3 result in gene fusions and overexpression of chimeric fusion proteins that retain the C-terminal DNA binding domain of TFE3.
T4 300-548 Sentence denotes TFE3 is a member of the MiTF/TFE transcription factor family and Xp11.2 translocations found in sporadic RCC involving TFE3 result in gene fusions and overexpression of chimeric fusion proteins that retain the C-terminal DNA binding domain of TFE3.
TextSentencer_T5 549-710 Sentence denotes We found that GPNMB expression, which is regulated by MiTF, was greatly elevated in renal cancer cells harboring either TFE3 translocations or FLCN inactivation.
T5 549-710 Sentence denotes We found that GPNMB expression, which is regulated by MiTF, was greatly elevated in renal cancer cells harboring either TFE3 translocations or FLCN inactivation.
TextSentencer_T6 711-866 Sentence denotes Since TFE3 is implicated in RCC, we hypothesized that elevated GPNMB expression was due to increased TFE3 activity resulting from the inactivation of FLCN.
T6 711-866 Sentence denotes Since TFE3 is implicated in RCC, we hypothesized that elevated GPNMB expression was due to increased TFE3 activity resulting from the inactivation of FLCN.
TextSentencer_T7 867-1019 Sentence denotes METHODOLOGY/PRINCIPAL FINDINGS: TFE3 knockdown reduced GPNMB expression in renal cancer cells harboring either TFE3 translocations or FLCN inactivation.
T7 867-1019 Sentence denotes METHODOLOGY/PRINCIPAL FINDINGS: TFE3 knockdown reduced GPNMB expression in renal cancer cells harboring either TFE3 translocations or FLCN inactivation.
TextSentencer_T8 1020-1106 Sentence denotes Moreover, FLCN knockdown induced GPNMB expression in FLCN-restored renal cancer cells.
T8 1020-1106 Sentence denotes Moreover, FLCN knockdown induced GPNMB expression in FLCN-restored renal cancer cells.
TextSentencer_T9 1107-1180 Sentence denotes Conversely, wildtype FLCN suppressed GPNMB expression in FLCN-null cells.
T9 1107-1180 Sentence denotes Conversely, wildtype FLCN suppressed GPNMB expression in FLCN-null cells.
TextSentencer_T10 1181-1508 Sentence denotes FLCN inactivation was correlated with increased TFE3 transcriptional activity accompanied by its nuclear localization as revealed by elevated GPNMB mRNA and protein expression, and predominantly nuclear immunostaining of TFE3 in renal cancer cells, mouse embryo fibroblast cells, mouse kidneys and mouse and human renal tumors.
T10 1181-1508 Sentence denotes FLCN inactivation was correlated with increased TFE3 transcriptional activity accompanied by its nuclear localization as revealed by elevated GPNMB mRNA and protein expression, and predominantly nuclear immunostaining of TFE3 in renal cancer cells, mouse embryo fibroblast cells, mouse kidneys and mouse and human renal tumors.
TextSentencer_T11 1509-1632 Sentence denotes Nuclear localization of TFE3 was associated with TFE3 post-translational modifications including decreased phosphorylation.
T11 1509-1632 Sentence denotes Nuclear localization of TFE3 was associated with TFE3 post-translational modifications including decreased phosphorylation.
TextSentencer_T12 1633-1658 Sentence denotes CONCLUSIONS/SIGNIFICANCE:
T12 1633-1658 Sentence denotes CONCLUSIONS/SIGNIFICANCE:
TextSentencer_T13 1659-1792 Sentence denotes Increased TFE3 activity is a downstream event induced by FLCN inactivation and is likely to be important for renal tumor development.
T13 1659-1792 Sentence denotes Increased TFE3 activity is a downstream event induced by FLCN inactivation and is likely to be important for renal tumor development.
TextSentencer_T14 1793-2013 Sentence denotes This study provides an important novel mechanism for induction of TFE3 activity in addition to TFE3 overexpression resulting from Xp11.2 translocations, suggesting that TFE3 may be more broadly involved in tumorigenesis.
T14 1793-2013 Sentence denotes This study provides an important novel mechanism for induction of TFE3 activity in addition to TFE3 overexpression resulting from Xp11.2 translocations, suggesting that TFE3 may be more broadly involved in tumorigenesis.