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PubMed:21189258 JSONTXT 24 Projects

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Id Subject Object Predicate Lexical cue
T1 0-140 Sentence denotes Inhibition of proinflammatory RANTES expression by TGF-beta1 is mediated by glycogen synthase kinase-3beta-dependent beta-catenin signaling.
T2 141-213 Sentence denotes TGF-β1 is a pleiotropic cytokine with potent anti-inflammation property.
T3 214-310 Sentence denotes However, the mechanisms underlying TGF-β1 suppression of inflammation remain largely unexplored.
T4 311-454 Sentence denotes In this study, we demonstrated that TGF-β1 inhibited TNF-α- or IL-1-induced RANTES expression in human kidney tubular epithelial cells (HKC-8).
T5 455-618 Sentence denotes To delineate the mechanism by which TGF-β1 inhibits RANTES expression, we examined the potential signal pathway activated by TGF-β1 in suppressing NF-κB signaling.
T6 619-766 Sentence denotes TGF-β1 affected neither TNF-α-induced IκBα phosphorylation and subsequent degradation, nor p65 NF-κB phosphorylation and its nuclear translocation.
T7 767-938 Sentence denotes However, TGF-β1 could inhibit p65 and p50 binding to the κB site in human RANTES promoter as revealed by chromatin immunoprecipitation assay and protein-DNA binding assay.
T8 939-1074 Sentence denotes We found that TGF-β1 induced glycogen synthase kinase-3β (GSK-3β) phosphorylation on Ser-9 in HKC-8 cells, leading to its inactivation.
T9 1075-1260 Sentence denotes Knockdown of GSK-3β mimicked TGF-β1 and inhibited RANTES induction, whereas overexpression of GSK-3β abolished the inhibitory effect of TGF-β1 and completely restored RANTES expression.
T10 1261-1376 Sentence denotes Furthermore, TGF-β1 induced the dephosphorylation and activation of β-catenin, a major downstream target of GSK-3β.
T11 1377-1519 Sentence denotes Ectopic expression of constitutively active β-catenin mimicked the TGF-β1 effect and completely suppressed RANTES expression induced by TNF-α.
T12 1520-1739 Sentence denotes Interestingly, TGF-β1 induced a physical interaction between β-catenin and p65 NF-κB, which prevented p65 binding to the κB site, sequestered its trans-activating activity, and repressed p65-mediated gene transcription.
T13 1740-1875 Sentence denotes We conclude that TGF-β1 inhibition of proinflammatory RANTES expression is mediated by β-catenin-triggered blockade of NF-κB signaling.