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PubMed:2116413 JSONTXT 28 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-103 Sentence denotes Mutations that substitute serine for glycine alpha 1-598 and glycine alpha 1-631 in type I procollagen.
T1 0-103 Sentence denotes Mutations that substitute serine for glycine alpha 1-598 and glycine alpha 1-631 in type I procollagen.
TextSentencer_T2 104-259 Sentence denotes The effects on thermal unfolding of the triple helix are position-specific and demonstrate that the protein unfolds through a series of cooperative blocks.
T2 104-259 Sentence denotes The effects on thermal unfolding of the triple helix are position-specific and demonstrate that the protein unfolds through a series of cooperative blocks.
TextSentencer_T3 260-426 Sentence denotes Cultured skin fibroblasts from two probands with lethal variants of osteogenesis imperfecta synthesized type I procollagen that was posttranslationally over-modified.
T3 260-426 Sentence denotes Cultured skin fibroblasts from two probands with lethal variants of osteogenesis imperfecta synthesized type I procollagen that was posttranslationally over-modified.
TextSentencer_T4 427-724 Sentence denotes Analysis of cDNAs and genomic DNAs from the two probands demonstrated that proband I had a single-base mutation that converted the codon for glycine alpha 1-631 to a codon for serine, and proband II had a single-base mutation that converted the codon for glycine alpha 1-598 to a codon for serine.
T4 427-724 Sentence denotes Analysis of cDNAs and genomic DNAs from the two probands demonstrated that proband I had a single-base mutation that converted the codon for glycine alpha 1-631 to a codon for serine, and proband II had a single-base mutation that converted the codon for glycine alpha 1-598 to a codon for serine.
TextSentencer_T5 725-940 Sentence denotes Although the two serine-for-glycine substitutions were separated by only 35 residues, they had markedly different effects on the thermal unfolding of the collagen triple helix as assayed by brief protease digestion.
T5 725-940 Sentence denotes Although the two serine-for-glycine substitutions were separated by only 35 residues, they had markedly different effects on the thermal unfolding of the collagen triple helix as assayed by brief protease digestion.
TextSentencer_T6 941-1060 Sentence denotes The type I procollagen from proband I (serine alpha 1-631) had an essentially normal temperature for thermal unfolding.
T6 941-1060 Sentence denotes The type I procollagen from proband I (serine alpha 1-631) had an essentially normal temperature for thermal unfolding.
TextSentencer_T7 1061-1227 Sentence denotes In contrast, type I procollagen from proband II (serine alpha 1-598) was cleaved to readily identifiable intermediate fragments of about 630 residues at 20 degrees C.
T7 1061-1227 Sentence denotes In contrast, type I procollagen from proband II (serine alpha 1-598) was cleaved to readily identifiable intermediate fragments of about 630 residues at 20 degrees C.
TextSentencer_T8 1228-1441 Sentence denotes With procollagens from both probands, collagenase A fragments containing the first 775 amino acids of the alpha chain domains had a lowered temperature for thermal unfolding as assayed by brief protease digestion.
T8 1228-1441 Sentence denotes With procollagens from both probands, collagenase A fragments containing the first 775 amino acids of the alpha chain domains had a lowered temperature for thermal unfolding as assayed by brief protease digestion.
TextSentencer_T9 1442-1611 Sentence denotes The collagenase A fragments from proband I were cleaved to intermediates of about 600 amino acids at 36 degrees C and to fragments of about 510 residues at 37 degrees C.
T9 1442-1611 Sentence denotes The collagenase A fragments from proband I were cleaved to intermediates of about 600 amino acids at 36 degrees C and to fragments of about 510 residues at 37 degrees C.
TextSentencer_T10 1612-1823 Sentence denotes The collagenase A fragments from proband II were cleaved to intermediates of about 630 residues at 32 degrees C, to fragments of about 600 residues at 36 degrees C, and to fragments of about 510 at 37 degrees C.
T10 1612-1823 Sentence denotes The collagenase A fragments from proband II were cleaved to intermediates of about 630 residues at 32 degrees C, to fragments of about 600 residues at 36 degrees C, and to fragments of about 510 at 37 degrees C.
TextSentencer_T11 1824-2007 Sentence denotes The fragments of about 510 residues from both mutated procollagens were more stable to protease digestion than the collagenase A fragments of 775 residues from normal type I collagen.
T11 1824-2007 Sentence denotes The fragments of about 510 residues from both mutated procollagens were more stable to protease digestion than the collagenase A fragments of 775 residues from normal type I collagen.
TextSentencer_T12 2008-2147 Sentence denotes The results demonstrate that the effects of glycine substitutions on the thermal unfolding of type I collagen are highly position-specific.
T12 2008-2147 Sentence denotes The results demonstrate that the effects of glycine substitutions on the thermal unfolding of type I collagen are highly position-specific.
TextSentencer_T13 2148-2374 Sentence denotes They also provide direct evidence for previous indications that the triple helix of the protein undergoes micro-unfolding of a series of relatively independent "cooperative blocks" in the predenaturation range of temperatures.
T13 2148-2374 Sentence denotes They also provide direct evidence for previous indications that the triple helix of the protein undergoes micro-unfolding of a series of relatively independent "cooperative blocks" in the predenaturation range of temperatures.