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PubMed:21135538 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-76 Sentence denotes Overexpression of Dyrk1A causes the defects in synaptic vesicle endocytosis.
T1 0-76 Sentence denotes Overexpression of Dyrk1A causes the defects in synaptic vesicle endocytosis.
TextSentencer_T2 77-272 Sentence denotes Trisomy 21-linked Dyrk1A (dual-specificity tyrosine phosphorylation-regulated kinase 1A) overexpression is implicated in pathogenic mechanisms underlying mental retardation in Down syndrome (DS).
T2 77-272 Sentence denotes Trisomy 21-linked Dyrk1A (dual-specificity tyrosine phosphorylation-regulated kinase 1A) overexpression is implicated in pathogenic mechanisms underlying mental retardation in Down syndrome (DS).
TextSentencer_T3 273-470 Sentence denotes It is known to phosphorylate multiple substrates including endocytic proteins in vitro, but the functional consequence of Dyrk1A-mediated phosphorylation on endocytosis has never been investigated.
T3 273-470 Sentence denotes It is known to phosphorylate multiple substrates including endocytic proteins in vitro, but the functional consequence of Dyrk1A-mediated phosphorylation on endocytosis has never been investigated.
TextSentencer_T4 471-661 Sentence denotes Here, we show that overexpression of Dyrk1A causes defects in clathrin-mediated endocytosis and specifically, in the recruitment of endocytic proteins to clathrin-coated pits in fibroblasts.
T4 471-661 Sentence denotes Here, we show that overexpression of Dyrk1A causes defects in clathrin-mediated endocytosis and specifically, in the recruitment of endocytic proteins to clathrin-coated pits in fibroblasts.
TextSentencer_T5 662-791 Sentence denotes Synaptic vesicle endocytosis also significantly slowed down as a result of Dyrk1A overexpression in cultured hippocampal neurons.
T5 662-791 Sentence denotes Synaptic vesicle endocytosis also significantly slowed down as a result of Dyrk1A overexpression in cultured hippocampal neurons.
TextSentencer_T6 792-846 Sentence denotes These effects are dependent on Dyrk1A kinase activity.
T6 792-846 Sentence denotes These effects are dependent on Dyrk1A kinase activity.
TextSentencer_T7 847-1019 Sentence denotes The inhibitory effect of Dyrk1A on synaptic vesicle endocytosis was confirmed in neuronal cultures derived from transgenic mice overexpressing Dyrk1A at levels found in DS.
T7 847-1019 Sentence denotes The inhibitory effect of Dyrk1A on synaptic vesicle endocytosis was confirmed in neuronal cultures derived from transgenic mice overexpressing Dyrk1A at levels found in DS.
TextSentencer_T8 1020-1146 Sentence denotes Pharmacological blockade of Dyrk1A with epigallocatechin gallate rescued the endocytic phenotypes found in transgenic neurons.
T8 1020-1146 Sentence denotes Pharmacological blockade of Dyrk1A with epigallocatechin gallate rescued the endocytic phenotypes found in transgenic neurons.
TextSentencer_T9 1147-1377 Sentence denotes Together, our results suggest that aberrant Dyrk1A-mediated phosphorylation of the endocytic machinery perturbs synaptic vesicle endocytosis, which may contribute to synaptic dysfunctions and cognitive deficits associated with DS.
T9 1147-1377 Sentence denotes Together, our results suggest that aberrant Dyrk1A-mediated phosphorylation of the endocytic machinery perturbs synaptic vesicle endocytosis, which may contribute to synaptic dysfunctions and cognitive deficits associated with DS.