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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-126 Sentence denotes 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer.
T1 0-126 Sentence denotes 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer.
TextSentencer_T2 127-138 Sentence denotes BACKGROUND:
T2 127-138 Sentence denotes BACKGROUND:
TextSentencer_T3 139-472 Sentence denotes A novel series of methylene-substituted DIMs (C-DIMs), namely 1,1-bis(3'-indolyl)-1-(p-substituted phenyl)methanes containing t-butyl (DIM-C-pPhtBu) and phenyl (DIM-C-pPhC6H5) groups inhibit proliferation of invasive estrogen receptor-negative MDA-MB-231 and MDA-MB-453 human breast cancer cell lines with IC50 values between 1-5 uM.
T3 139-472 Sentence denotes A novel series of methylene-substituted DIMs (C-DIMs), namely 1,1-bis(3'-indolyl)-1-(p-substituted phenyl)methanes containing t-butyl (DIM-C-pPhtBu) and phenyl (DIM-C-pPhC6H5) groups inhibit proliferation of invasive estrogen receptor-negative MDA-MB-231 and MDA-MB-453 human breast cancer cell lines with IC50 values between 1-5 uM.
TextSentencer_T4 473-564 Sentence denotes The main purpose of this study was to investigate the pathways of C-DIM-induced cell death.
T4 473-564 Sentence denotes The main purpose of this study was to investigate the pathways of C-DIM-induced cell death.
TextSentencer_T5 565-573 Sentence denotes METHODS:
T5 565-573 Sentence denotes METHODS:
TextSentencer_T6 574-841 Sentence denotes The effects of the C-DIMs on apoptotic, necrotic and autophagic cell death were determined using caspase inhibitors, measurement of lactate dehydrogenase release, and several markers of autophagy including Beclin and light chain associated protein 3 expression (LC3).
T6 574-841 Sentence denotes The effects of the C-DIMs on apoptotic, necrotic and autophagic cell death were determined using caspase inhibitors, measurement of lactate dehydrogenase release, and several markers of autophagy including Beclin and light chain associated protein 3 expression (LC3).
TextSentencer_T7 842-850 Sentence denotes RESULTS:
T7 842-850 Sentence denotes RESULTS:
TextSentencer_T8 851-945 Sentence denotes The C-DIM compounds did not induce apoptosis and only DIM-C-pPhCF3 exhibited necrotic effects.
T8 851-945 Sentence denotes The C-DIM compounds did not induce apoptosis and only DIM-C-pPhCF3 exhibited necrotic effects.
TextSentencer_T9 946-1285 Sentence denotes However, treatment of MDA-MB-231 and MDA-MB-453 cells with C-DIMs resulted in accumulation of LC3-II compared to LC3-I protein, a characteristic marker of autophagy, and transient transfection of green fluorescent protein-LC3 also revealed that treatment with C-DIMs induced a redistribution of LC3 to autophagosomes after C-DIM treatment.
T9 946-1285 Sentence denotes However, treatment of MDA-MB-231 and MDA-MB-453 cells with C-DIMs resulted in accumulation of LC3-II compared to LC3-I protein, a characteristic marker of autophagy, and transient transfection of green fluorescent protein-LC3 also revealed that treatment with C-DIMs induced a redistribution of LC3 to autophagosomes after C-DIM treatment.
TextSentencer_T10 1286-1559 Sentence denotes In addition, the autofluorescent drug monodansylcadaverine (MDC), a specific autophagolysosome marker, accumulated in vacuoles after C-DIM treatment, and western blot analysis of lysates from cells treated with C-DIMs showed that the Beclin 1/Bcl-2 protein ratio increased.
T10 1286-1559 Sentence denotes In addition, the autofluorescent drug monodansylcadaverine (MDC), a specific autophagolysosome marker, accumulated in vacuoles after C-DIM treatment, and western blot analysis of lysates from cells treated with C-DIMs showed that the Beclin 1/Bcl-2 protein ratio increased.
TextSentencer_T11 1560-1571 Sentence denotes CONCLUSION:
T11 1560-1571 Sentence denotes CONCLUSION:
TextSentencer_T12 1572-1740 Sentence denotes The results suggest that C-DIM compounds may represent a new mechanism-based agent for treating drug-resistant ER-negative breast tumors through induction of autophagy.
T12 1572-1740 Sentence denotes The results suggest that C-DIM compounds may represent a new mechanism-based agent for treating drug-resistant ER-negative breast tumors through induction of autophagy.