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PubMed:21128244 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-54 Sentence denotes Differential aminoacylase expression in neuroblastoma.
T1 0-54 Sentence denotes Differential aminoacylase expression in neuroblastoma.
TextSentencer_T2 55-170 Sentence denotes Neuroblastoma, a cancer of the sympathetic nervous system, is the most common extracranial solid tumor in children.
T2 55-170 Sentence denotes Neuroblastoma, a cancer of the sympathetic nervous system, is the most common extracranial solid tumor in children.
TextSentencer_T3 171-316 Sentence denotes MYCN amplification and increased BDNF/TrkB signaling are features of high-risk tumors; yet, only ˜25% of malignant tumors display these features.
T3 171-316 Sentence denotes MYCN amplification and increased BDNF/TrkB signaling are features of high-risk tumors; yet, only ˜25% of malignant tumors display these features.
TextSentencer_T4 317-404 Sentence denotes Thus, the identification of additional biomarkers and therapeutic targets is essential.
T4 317-404 Sentence denotes Thus, the identification of additional biomarkers and therapeutic targets is essential.
TextSentencer_T5 405-701 Sentence denotes As aminoacylase 1 (ACY1), an amino acid deacetylase, is a putative tumor suppressor in small cell lung and renal cell carcinomas, we investigated whether it or the other family members aspartoacylase (ASPA, aminoacylase 2) or aminoacylase 3 (ACY3) could serve a similar function in neuroblastoma.
T5 405-701 Sentence denotes As aminoacylase 1 (ACY1), an amino acid deacetylase, is a putative tumor suppressor in small cell lung and renal cell carcinomas, we investigated whether it or the other family members aspartoacylase (ASPA, aminoacylase 2) or aminoacylase 3 (ACY3) could serve a similar function in neuroblastoma.
TextSentencer_T6 702-896 Sentence denotes Aminoacylase expression was examined in TrkB-positive, MYCN-amplified (SMS-KCNR and SK-N-BE) and TrkB-negative, non-MYCN-amplified (SK-N-AS, SK-N-SH, SH-SY5Y and SH-EP) neuroblastoma cell lines.
T6 702-896 Sentence denotes Aminoacylase expression was examined in TrkB-positive, MYCN-amplified (SMS-KCNR and SK-N-BE) and TrkB-negative, non-MYCN-amplified (SK-N-AS, SK-N-SH, SH-SY5Y and SH-EP) neuroblastoma cell lines.
TextSentencer_T7 897-1021 Sentence denotes Each aminoacylase exhibited distinct spatial localization (i.e., cytosolic ACY1, membrane-associated ASPA and nuclear ACY3).
T7 897-1021 Sentence denotes Each aminoacylase exhibited distinct spatial localization (i.e., cytosolic ACY1, membrane-associated ASPA and nuclear ACY3).
TextSentencer_T8 1022-1215 Sentence denotes When SK-N-SH cells were treated with neural differentiation agents (e.g., retinoic acid and cAMP) in media containing 10% serum, ACY1 was the only aminoacylase whose expression was upregulated.
T8 1022-1215 Sentence denotes When SK-N-SH cells were treated with neural differentiation agents (e.g., retinoic acid and cAMP) in media containing 10% serum, ACY1 was the only aminoacylase whose expression was upregulated.
TextSentencer_T9 1216-1282 Sentence denotes ASPA was primarily expressed in SH-EP cells of a glial sublineage.
T9 1216-1282 Sentence denotes ASPA was primarily expressed in SH-EP cells of a glial sublineage.
TextSentencer_T10 1283-1357 Sentence denotes ACY3 was more highly expressed in the TrkB-positive, MYCN-amplified lines.
T10 1283-1357 Sentence denotes ACY3 was more highly expressed in the TrkB-positive, MYCN-amplified lines.
TextSentencer_T11 1358-1553 Sentence denotes All three aminoacylases were expressed in normal human adrenal gland, a common site of neuroblastoma origin, but only ACY1 and ACY3 displayed detectable expression in primary neuroblastoma tumor.
T11 1358-1553 Sentence denotes All three aminoacylases were expressed in normal human adrenal gland, a common site of neuroblastoma origin, but only ACY1 and ACY3 displayed detectable expression in primary neuroblastoma tumor.
TextSentencer_T12 1554-1749 Sentence denotes Bioinformatics data mining of Kaplan-Meier survival revealed that high ACY3 expression is correlated with poor prognosis, whereas low expression of ACY1 or ASPA is correlated with poor prognosis.
T12 1554-1749 Sentence denotes Bioinformatics data mining of Kaplan-Meier survival revealed that high ACY3 expression is correlated with poor prognosis, whereas low expression of ACY1 or ASPA is correlated with poor prognosis.
TextSentencer_T13 1750-1831 Sentence denotes These data suggest that aminoacylase expression is dysregulated in neuroblastoma.
T13 1750-1831 Sentence denotes These data suggest that aminoacylase expression is dysregulated in neuroblastoma.