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PubMed:21067489 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-21 Sentence denotes Diabetic retinopathy:
T1 0-21 Sentence denotes Diabetic retinopathy:
TextSentencer_T2 22-107 Sentence denotes Validation study of ALR2, RAGE, iNOS and TNFB gene variants in a south Indian cohort.
T2 22-107 Sentence denotes Validation study of ALR2, RAGE, iNOS and TNFB gene variants in a south Indian cohort.
TextSentencer_T3 108-116 Sentence denotes PURPOSE:
T3 108-116 Sentence denotes PURPOSE:
TextSentencer_T4 117-695 Sentence denotes We previously reported the association of the Z-2 allele of the promoter dinucleotide repeat in the Aldose reductase (ALR2) gene, the (CCTTT)₁₅ allele in the promoter of inductible nitric oxide synthase (iNOS) gene, and the (GT)₁₃ promoter polymorphism in the tumor necrosis factor β (TNFB) gene with an increased risk for diabetic retinopathy (DR), and the Gly82Ser polymorphism in the receptor for advanced glycation end products (RAGE) gene and the (GT)₉ allele of the TNFB gene with low-risk for DR in a hospital-based self-reported type 2 diabetes mellitus (T2DM) patients.
T4 117-695 Sentence denotes We previously reported the association of the Z-2 allele of the promoter dinucleotide repeat in the Aldose reductase (ALR2) gene, the (CCTTT)₁₅ allele in the promoter of inductible nitric oxide synthase (iNOS) gene, and the (GT)₁₃ promoter polymorphism in the tumor necrosis factor β (TNFB) gene with an increased risk for diabetic retinopathy (DR), and the Gly82Ser polymorphism in the receptor for advanced glycation end products (RAGE) gene and the (GT)₉ allele of the TNFB gene with low-risk for DR in a hospital-based self-reported type 2 diabetes mellitus (T2DM) patients.
TextSentencer_T5 696-812 Sentence denotes We have repeated the study in a population-based south Indian cohort to validate the same variations in these genes.
T5 696-812 Sentence denotes We have repeated the study in a population-based south Indian cohort to validate the same variations in these genes.
TextSentencer_T6 813-835 Sentence denotes MATERIALS AND METHODS:
T6 813-835 Sentence denotes MATERIALS AND METHODS:
TextSentencer_T7 836-1132 Sentence denotes Type 2 diabetic patients with and without retinopathy (DR+ and DR- respectively) were recruited. (CA)(n) repeat, Gly82Ser, (CCTTT)(n) repeat and (GT)(n) repeat in ALR2, RAGE, iNOS and TNFB genes respectively were genotyped and their frequencies were analyzed using the relevant statistical tests.
T7 836-1132 Sentence denotes Type 2 diabetic patients with and without retinopathy (DR+ and DR- respectively) were recruited. (CA)(n) repeat, Gly82Ser, (CCTTT)(n) repeat and (GT)(n) repeat in ALR2, RAGE, iNOS and TNFB genes respectively were genotyped and their frequencies were analyzed using the relevant statistical tests.
TextSentencer_T8 1133-1141 Sentence denotes RESULTS:
T8 1133-1141 Sentence denotes RESULTS:
TextSentencer_T9 1142-1244 Sentence denotes Different allelic associations were observed in the present study as compared to our previous reports.
T9 1142-1244 Sentence denotes Different allelic associations were observed in the present study as compared to our previous reports.
TextSentencer_T10 1245-1370 Sentence denotes Z+2 allele of ALR2, 13-repeat genotype of iNOS, 15-repeat genotype of TNF-β, genes were associated with susceptibility to DR.
T10 1245-1370 Sentence denotes Z+2 allele of ALR2, 13-repeat genotype of iNOS, 15-repeat genotype of TNF-β, genes were associated with susceptibility to DR.
TextSentencer_T11 1371-1460 Sentence denotes Gly82Ser polymorphisms of the RAGE gene were not associated with DR in the present study.
T11 1371-1460 Sentence denotes Gly82Ser polymorphisms of the RAGE gene were not associated with DR in the present study.
TextSentencer_T12 1461-1472 Sentence denotes CONCLUSION:
T12 1461-1472 Sentence denotes CONCLUSION:
TextSentencer_T13 1473-1719 Sentence denotes The present data show a difference in the association of variations in ALR2, iNOS and TNFB genes with DR, when compared to our previous reports; this could be attributed to differences between the study populations of the past and present report.
T13 1473-1719 Sentence denotes The present data show a difference in the association of variations in ALR2, iNOS and TNFB genes with DR, when compared to our previous reports; this could be attributed to differences between the study populations of the past and present report.