| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-98 |
Sentence |
denotes |
Lineage-specific effects of 1,25-dihydroxyvitamin D(3) on the development of effector CD4 T cells. |
| T2 |
99-156 |
Sentence |
denotes |
Vitamin D deficiency is implicated in autoimmune disease. |
| T3 |
157-403 |
Sentence |
denotes |
We therefore evaluated the effects of 1α,25-dihydroxyvitamin D(3) (1,25-D(3)), the active form of vitamin D, on the development of T helper 1 (Th1), Th17, and Th9 cells, which are implicated in the pathogenesis of different types of autoimmunity. |
| T4 |
404-569 |
Sentence |
denotes |
1,25-D(3) compromised the development of Th17 and Th9 cells, including IL-22-expressing cells while simultaneously increasing the frequency of IL-10-competent cells. |
| T5 |
570-743 |
Sentence |
denotes |
Relative to Th17 and Th9 cells, the effects of 1,25-D(3) on Th1 cells were modest, reflecting the significantly reduced levels of the receptor for vitamin D in this lineage. |
| T6 |
744-936 |
Sentence |
denotes |
The use of cells deficient in IL-10 or antibodies that block IL-10 signaling abolished the inhibitory effect of 1,25-D(3) on Th9 cells but had no effect on inhibition of Th17 cell frequencies. |
| T7 |
937-1110 |
Sentence |
denotes |
Thus, the induction of IL-10 in cultures of Th9 cells is an important mechanism by which 1,25-D(3) compromises Th9 development but does not explain inhibition of Th17 cells. |
| T8 |
1111-1354 |
Sentence |
denotes |
A survey of select representatives of the Th17 transcriptome revealed that the levels of mRNA that encode RORγt, IL-17A, IL-17F, IL-23R, and IL-22, were reduced by 1,25-D(3), whereas IL-21 and aryl hydrocarbon receptor mRNA remained unchanged. |
| T9 |
1355-1538 |
Sentence |
denotes |
These data suggest that vitamin D deficiency may promote autoimmunity by favoring the inordinate production of Th17 and Th9 cells at the expense of regulatory IL-10-producing T cells. |
