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PubMed:20974637 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-109 Sentence denotes Calmodulin and calmodulin-dependent protein kinase II inhibit hormone secretion in human parathyroid adenoma.
T1 0-109 Sentence denotes Calmodulin and calmodulin-dependent protein kinase II inhibit hormone secretion in human parathyroid adenoma.
TextSentencer_T2 110-216 Sentence denotes Intracellular calcium ([Ca(2+)](i)) is the most relevant modulator of parathyroid hormone (PTH) secretion.
T2 110-216 Sentence denotes Intracellular calcium ([Ca(2+)](i)) is the most relevant modulator of parathyroid hormone (PTH) secretion.
TextSentencer_T3 217-370 Sentence denotes Uniquely, an increase in [Ca(2+)](i) results in an inhibition of PTH secretion, and it probably exerts its function via calcium-binding protein pathways.
T3 217-370 Sentence denotes Uniquely, an increase in [Ca(2+)](i) results in an inhibition of PTH secretion, and it probably exerts its function via calcium-binding protein pathways.
TextSentencer_T4 371-564 Sentence denotes The ubiquitous calcium-binding proteins, calmodulin and calmodulin-dependent protein kinase II (CaMKII), have well-established roles in regulated exocytosis in neurons and neuroendocrine cells.
T4 371-564 Sentence denotes The ubiquitous calcium-binding proteins, calmodulin and calmodulin-dependent protein kinase II (CaMKII), have well-established roles in regulated exocytosis in neurons and neuroendocrine cells.
TextSentencer_T5 565-643 Sentence denotes However, their roles in parathyroid cells and PTH secretion are still unclear.
T5 565-643 Sentence denotes However, their roles in parathyroid cells and PTH secretion are still unclear.
TextSentencer_T6 644-828 Sentence denotes Using reverse transcription-PCR and western blot analysis, we have demonstrated the expression of calmodulin and CaMKII in human normal parathyroid and parathyroid chief cell adenomas.
T6 644-828 Sentence denotes Using reverse transcription-PCR and western blot analysis, we have demonstrated the expression of calmodulin and CaMKII in human normal parathyroid and parathyroid chief cell adenomas.
TextSentencer_T7 829-1033 Sentence denotes Blocking of calmodulin and CaMKII activity by the specific antagonists calmidazolium and KN-62 respectively caused a rise in PTH secretion from parathyroid adenoma cells in spite of increased [Ca(2+)](i).
T7 829-1033 Sentence denotes Blocking of calmodulin and CaMKII activity by the specific antagonists calmidazolium and KN-62 respectively caused a rise in PTH secretion from parathyroid adenoma cells in spite of increased [Ca(2+)](i).
TextSentencer_T8 1034-1213 Sentence denotes The inhibitory effect of Ca(2+) calmodulin on PTH secretion may be due to the absence of synaptotagmin 1 protein in parathyroid adenomas, as demonstrated by western blot analysis.
T8 1034-1213 Sentence denotes The inhibitory effect of Ca(2+) calmodulin on PTH secretion may be due to the absence of synaptotagmin 1 protein in parathyroid adenomas, as demonstrated by western blot analysis.
TextSentencer_T9 1214-1407 Sentence denotes An increased extracellular calcium level acutely lowered the amount of active phosphorylated CaMKII (pCaMKII) in adenoma cells in vitro, indicating the physiological importance of this pathway.
T9 1214-1407 Sentence denotes An increased extracellular calcium level acutely lowered the amount of active phosphorylated CaMKII (pCaMKII) in adenoma cells in vitro, indicating the physiological importance of this pathway.
TextSentencer_T10 1408-1571 Sentence denotes Moreover, a negative correlation between the levels of pCaMKII in parathyroid adenomas and serum calcium was found in 20 patients with primary hyperparathyroidism.
T10 1408-1571 Sentence denotes Moreover, a negative correlation between the levels of pCaMKII in parathyroid adenomas and serum calcium was found in 20 patients with primary hyperparathyroidism.
TextSentencer_T11 1572-1745 Sentence denotes Taken together, these results show that calmodulin negatively contributes to the regulation of PTH secretion in parathyroid adenoma, at least partially via a CaMKII pathway.
T11 1572-1745 Sentence denotes Taken together, these results show that calmodulin negatively contributes to the regulation of PTH secretion in parathyroid adenoma, at least partially via a CaMKII pathway.