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Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-88 Sentence denotes Galectin multimerization and lattice formation are regulated by linker region structure.
T1 0-88 Sentence denotes Galectin multimerization and lattice formation are regulated by linker region structure.
T1 0-88 Sentence denotes Galectin multimerization and lattice formation are regulated by linker region structure.
TextSentencer_T2 89-195 Sentence denotes Galectins regulate cellular functions by binding to glycan ligands on cell surface glycoprotein receptors.
T2 89-195 Sentence denotes Galectins regulate cellular functions by binding to glycan ligands on cell surface glycoprotein receptors.
T2 89-195 Sentence denotes Galectins regulate cellular functions by binding to glycan ligands on cell surface glycoprotein receptors.
TextSentencer_T3 196-431 Sentence denotes Prototype galectins, such as galectin-1, are one carbohydrate recognition domain (CRD) monomers that noncovalently dimerize, whereas tandem-repeat galectins, such as galectin-9, have two non-identical CRDs connected by a linker domain.
T3 196-431 Sentence denotes Prototype galectins, such as galectin-1, are one carbohydrate recognition domain (CRD) monomers that noncovalently dimerize, whereas tandem-repeat galectins, such as galectin-9, have two non-identical CRDs connected by a linker domain.
T3 196-431 Sentence denotes Prototype galectins, such as galectin-1, are one carbohydrate recognition domain (CRD) monomers that noncovalently dimerize, whereas tandem-repeat galectins, such as galectin-9, have two non-identical CRDs connected by a linker domain.
TextSentencer_T4 432-613 Sentence denotes Dimerization of prototype galectins, or both CRDs in tandem-repeat galectins, is typically required for the crosslinking of glycoprotein receptors and subsequent cellular signaling.
T4 432-613 Sentence denotes Dimerization of prototype galectins, or both CRDs in tandem-repeat galectins, is typically required for the crosslinking of glycoprotein receptors and subsequent cellular signaling.
T4 432-613 Sentence denotes Dimerization of prototype galectins, or both CRDs in tandem-repeat galectins, is typically required for the crosslinking of glycoprotein receptors and subsequent cellular signaling.
TextSentencer_T5 614-767 Sentence denotes Several studies have found that tandem-repeat galectins are more potent than prototype galectins in triggering many cell responses, including cell death.
T5 614-767 Sentence denotes Several studies have found that tandem-repeat galectins are more potent than prototype galectins in triggering many cell responses, including cell death.
T5 614-767 Sentence denotes Several studies have found that tandem-repeat galectins are more potent than prototype galectins in triggering many cell responses, including cell death.
TextSentencer_T6 768-884 Sentence denotes These differences could be due to CRD specificity, the presence or absence of a linker domain between CRDs, or both.
T6 768-884 Sentence denotes These differences could be due to CRD specificity, the presence or absence of a linker domain between CRDs, or both.
T6 768-884 Sentence denotes These differences could be due to CRD specificity, the presence or absence of a linker domain between CRDs, or both.
TextSentencer_T7 885-1264 Sentence denotes To interrogate the basis for the increased potency of tandem-repeat galectins compared with prototype galectins in triggering cell death, we created three tandem-repeat galectin constructs with different linker regions joining identical galectin-1 CRDs, so that any differences we observed would be due to the contribution of the linker region rather than due to CRD specificity.
T7 885-1264 Sentence denotes To interrogate the basis for the increased potency of tandem-repeat galectins compared with prototype galectins in triggering cell death, we created three tandem-repeat galectin constructs with different linker regions joining identical galectin-1 CRDs, so that any differences we observed would be due to the contribution of the linker region rather than due to CRD specificity.
T7 885-1264 Sentence denotes To interrogate the basis for the increased potency of tandem-repeat galectins compared with prototype galectins in triggering cell death, we created three tandem-repeat galectin constructs with different linker regions joining identical galectin-1 CRDs, so that any differences we observed would be due to the contribution of the linker region rather than due to CRD specificity.
TextSentencer_T8 1265-1650 Sentence denotes We found that random-coil or rigid α-helical linkers that permit separation of the two galectin-1 CRDs facilitated the formation of higher-order galectin multimers and that these galectins were more potent in binding to glycan ligands and cell surface glycoprotein receptors, as well as triggering T cell death, compared with native galectin-1 or a construct with a short rigid linker.
T8 1265-1650 Sentence denotes We found that random-coil or rigid α-helical linkers that permit separation of the two galectin-1 CRDs facilitated the formation of higher-order galectin multimers and that these galectins were more potent in binding to glycan ligands and cell surface glycoprotein receptors, as well as triggering T cell death, compared with native galectin-1 or a construct with a short rigid linker.
T8 1265-1650 Sentence denotes We found that random-coil or rigid α-helical linkers that permit separation of the two galectin-1 CRDs facilitated the formation of higher-order galectin multimers and that these galectins were more potent in binding to glycan ligands and cell surface glycoprotein receptors, as well as triggering T cell death, compared with native galectin-1 or a construct with a short rigid linker.
TextSentencer_T9 1651-1953 Sentence denotes Thus, the increased potency of tandem-repeat galectins compared with prototype galectins is likely due to the ability of the linker domain to permit intermolecular CRD interactions, resulting in the formation of higher-order multimers with increased valency, rather than differences in CRD specificity.
T9 1651-1953 Sentence denotes Thus, the increased potency of tandem-repeat galectins compared with prototype galectins is likely due to the ability of the linker domain to permit intermolecular CRD interactions, resulting in the formation of higher-order multimers with increased valency, rather than differences in CRD specificity.
T9 1651-1953 Sentence denotes Thus, the increased potency of tandem-repeat galectins compared with prototype galectins is likely due to the ability of the linker domain to permit intermolecular CRD interactions, resulting in the formation of higher-order multimers with increased valency, rather than differences in CRD specificity.