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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-111 Sentence denotes Expression regulation and function of heparan sulfate 6-O-endosulfatases in the spermatogonial stem cell niche.
T1 0-111 Sentence denotes Expression regulation and function of heparan sulfate 6-O-endosulfatases in the spermatogonial stem cell niche.
TextSentencer_T2 112-204 Sentence denotes Glial cell line-derived neurotrophic factor (GDNF) is a heparan sulfate (HS)-binding factor.
T2 112-204 Sentence denotes Glial cell line-derived neurotrophic factor (GDNF) is a heparan sulfate (HS)-binding factor.
TextSentencer_T3 205-327 Sentence denotes GDNF is produced by somatic Sertoli cells, where it signals to maintain spermatogonial stem cells (SSCs) and reproduction.
T3 205-327 Sentence denotes GDNF is produced by somatic Sertoli cells, where it signals to maintain spermatogonial stem cells (SSCs) and reproduction.
TextSentencer_T4 328-486 Sentence denotes Here, we investigate the roles of extracellular HS 6-O-endosulfatases (Sulfs), Sulf1 and Sulf2, in the matrix transmission of GDNF from Sertoli cells to SSCs.
T4 328-486 Sentence denotes Here, we investigate the roles of extracellular HS 6-O-endosulfatases (Sulfs), Sulf1 and Sulf2, in the matrix transmission of GDNF from Sertoli cells to SSCs.
TextSentencer_T5 487-652 Sentence denotes Although Sulfs are not required for testis formation, Sulf deficiency leads to the accelerated depletion of SSCs, a testis phenotype similar to that of GDNF+/- mice.
T5 487-652 Sentence denotes Although Sulfs are not required for testis formation, Sulf deficiency leads to the accelerated depletion of SSCs, a testis phenotype similar to that of GDNF+/- mice.
TextSentencer_T6 653-735 Sentence denotes Mechanistically, we show that Sulfs are expressed in GDNF-producing Sertoli cells.
T6 653-735 Sentence denotes Mechanistically, we show that Sulfs are expressed in GDNF-producing Sertoli cells.
TextSentencer_T7 736-845 Sentence denotes In addition, reduced Sulf activity profoundly worsens haplo-deficient GDNF phenotypes in our genetic studies.
T7 736-845 Sentence denotes In addition, reduced Sulf activity profoundly worsens haplo-deficient GDNF phenotypes in our genetic studies.
TextSentencer_T8 846-1085 Sentence denotes These findings establish a critical role of Sulfs in promoting GDNF signaling and support a model in which Sulfs regulate the bioavailability of GDNF by enzymatically remodeling HS 6-O-desulfation to release GDNF from matrix sequestration.
T8 846-1085 Sentence denotes These findings establish a critical role of Sulfs in promoting GDNF signaling and support a model in which Sulfs regulate the bioavailability of GDNF by enzymatically remodeling HS 6-O-desulfation to release GDNF from matrix sequestration.
TextSentencer_T9 1086-1228 Sentence denotes Further, Sertoli cell-specific transcriptional factor Wilm's tumor 1 (WT1) directly activates the transcription of both Sulf1 and Sulf2 genes.
T9 1086-1228 Sentence denotes Further, Sertoli cell-specific transcriptional factor Wilm's tumor 1 (WT1) directly activates the transcription of both Sulf1 and Sulf2 genes.
TextSentencer_T10 1229-1444 Sentence denotes Together, our studies not only identify Sulfs as essential regulators of GDNF signaling in the SSC niche, but also as direct downstream targets of WT1, thus establishing a physiological role of WT1 in Sertoli cells.
T10 1229-1444 Sentence denotes Together, our studies not only identify Sulfs as essential regulators of GDNF signaling in the SSC niche, but also as direct downstream targets of WT1, thus establishing a physiological role of WT1 in Sertoli cells.