> top > projects > sentences > docs > PubMed:20830616 > annotations
sentences Home  

PubMed:20830616 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-113 Sentence denotes Expression and epigenetic modulation of sonic hedgehog-GLI1 pathway genes in neuroblastoma cell lines and tumors.
T1 0-113 Sentence denotes Expression and epigenetic modulation of sonic hedgehog-GLI1 pathway genes in neuroblastoma cell lines and tumors.
TextSentencer_T2 114-223 Sentence denotes It is well known that sonic hedgehog signaling pathway plays a vital role during early embryonic development.
T2 114-223 Sentence denotes It is well known that sonic hedgehog signaling pathway plays a vital role during early embryonic development.
TextSentencer_T3 224-400 Sentence denotes It is also responsible for stem cell renewal and development of several cancers like colorectal and breast carcinoma and major brain tumors as medulloblastoma and glioblastoma.
T3 224-400 Sentence denotes It is also responsible for stem cell renewal and development of several cancers like colorectal and breast carcinoma and major brain tumors as medulloblastoma and glioblastoma.
TextSentencer_T4 401-511 Sentence denotes The role of sonic hedgehog signaling in the development of neuroblastoma has not been thoroughly investigated.
T4 401-511 Sentence denotes The role of sonic hedgehog signaling in the development of neuroblastoma has not been thoroughly investigated.
TextSentencer_T5 512-949 Sentence denotes In this study, we attempted to determine the expression of Bmi-1 stem cell marker and of Shh pathway downstream target genes glioma-associated oncogene homolog 1 (GLI1), protein patched homolog 1 (PTCH1), Cyclin D2, plakoglobin (γ catenin), NK2 homeobox 2 (NKX2.2), paired box gene 6 (PAX6), secreted frizzled-related protein 1 (SFRP1), and hedgehog interacting protein (HHIP) in 11 neuroblastoma cell lines and 41 neuroblastoma samples.
T5 512-949 Sentence denotes In this study, we attempted to determine the expression of Bmi-1 stem cell marker and of Shh pathway downstream target genes glioma-associated oncogene homolog 1 (GLI1), protein patched homolog 1 (PTCH1), Cyclin D2, plakoglobin (γ catenin), NK2 homeobox 2 (NKX2.2), paired box gene 6 (PAX6), secreted frizzled-related protein 1 (SFRP1), and hedgehog interacting protein (HHIP) in 11 neuroblastoma cell lines and 41 neuroblastoma samples.
TextSentencer_T6 950-1061 Sentence denotes Also, inhibition of the pathway was performed genetically by GLI1 knockdown siRNA or chemically by cyclopamine.
T6 950-1061 Sentence denotes Also, inhibition of the pathway was performed genetically by GLI1 knockdown siRNA or chemically by cyclopamine.
TextSentencer_T7 1062-1176 Sentence denotes After inhibition, low transcript expression was detected in downstream target genes like PTCH1, in the cell lines.
T7 1062-1176 Sentence denotes After inhibition, low transcript expression was detected in downstream target genes like PTCH1, in the cell lines.
TextSentencer_T8 1177-1366 Sentence denotes We further preformed promoter methylation studies of Cyclin D2, PTCH1, HHIP, and SFRP1 genes by melting curve analysis-based methylation assay (MCA-Meth) and methylation-specific PCR (MSP).
T8 1177-1366 Sentence denotes We further preformed promoter methylation studies of Cyclin D2, PTCH1, HHIP, and SFRP1 genes by melting curve analysis-based methylation assay (MCA-Meth) and methylation-specific PCR (MSP).
TextSentencer_T9 1367-1680 Sentence denotes Results revealed no methylation in Cyclin D2 gene promoter in neuroblastoma samples or in cell lines; one cell line (MHH-NB-11) showed PTCH1 methylation; 3/11 (27%) cell lines and 9/41 (22%) neuroblastoma samples showed HHIP methylation; and 3/11 (27%) cell lines and 11/41 (27%) samples showed SFRP1 methylation.
T9 1367-1680 Sentence denotes Results revealed no methylation in Cyclin D2 gene promoter in neuroblastoma samples or in cell lines; one cell line (MHH-NB-11) showed PTCH1 methylation; 3/11 (27%) cell lines and 9/41 (22%) neuroblastoma samples showed HHIP methylation; and 3/11 (27%) cell lines and 11/41 (27%) samples showed SFRP1 methylation.
TextSentencer_T10 1681-1936 Sentence denotes Taken together, our results suggest the possibility of two levels of control of the sonic hedgehog signaling pathway: transcriptional and epigenetic, which might offer new therapeutic possibilities to modulate the pathway and try to suppress tumor growth.
T10 1681-1936 Sentence denotes Taken together, our results suggest the possibility of two levels of control of the sonic hedgehog signaling pathway: transcriptional and epigenetic, which might offer new therapeutic possibilities to modulate the pathway and try to suppress tumor growth.